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[乳糖不耐受]

[Lactose intolerance].

作者信息

Rosado Jorge L

机构信息

Universidad Autónoma de Querétaro, CINDETEC A.C., Querétaro, Qro., México.

出版信息

Gac Med Mex. 2016 Sep;152 Suppl 1:67-73.

Abstract

The most common problem limiting milk consumption worldwide is lactose intolerance (LI), which is defined as the experience of gastrointestinal symptoms due to the intake of lactose-containing food. When symptoms ensue the intake of milk, the condition is referred as milk intolerance, and it may or may not be due to LI. The most common cause of LI is primary lactase deficiency which occurs in 30% of Mexican adults when one glass of milk is consumed (12-18 g of lactose). LI occurs in less than 15% of adults after the intake of this dose of lactose. Another cause of lactose intolerance is due to secondary lactase deficiency, which occurs because lactase is reduced due to diseases that affect the intestinal mucosa. Lactose intolerance can be eliminated or significantly reduced by elimination or reduction of the intake of milk and milk containing products. Recent studies demonstrate that when β-casein-A1 contained in milk is hydrolyzed it produces β-casomorphine-7 which is an opioid associated with milk intolerance.

摘要

全球范围内限制牛奶消费的最常见问题是乳糖不耐受(LI),它被定义为因摄入含乳糖食物而出现胃肠道症状。当饮用牛奶后出现症状时,这种情况被称为牛奶不耐受,它可能是也可能不是由乳糖不耐受引起的。乳糖不耐受最常见的原因是原发性乳糖酶缺乏,当一杯牛奶(12 - 18克乳糖)被饮用时,30%的墨西哥成年人会出现这种情况。摄入此剂量乳糖后,不到15%的成年人会出现乳糖不耐受。乳糖不耐受的另一个原因是继发性乳糖酶缺乏,这是由于影响肠黏膜的疾病导致乳糖酶减少所致。通过消除或减少牛奶及含奶制品的摄入,乳糖不耐受可以消除或显著减轻。最近的研究表明,牛奶中含有的β-酪蛋白-A1被水解时会产生β-酪蛋白吗啡-7,这是一种与牛奶不耐受相关的阿片类物质。

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