Tang Yunjia, Yan Wenhua, Sun Ling, Huang Jie, Qian Weiguo, Hou Miao, Lv Haitao
Department of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Ital J Pediatr. 2016 Sep 8;42(1):83. doi: 10.1186/s13052-016-0292-1.
Kawasaki disease (KD) is an illness of unknown etiology that mostly occurs in children under 5 years of age and is the leading cause of acquired heart disease all over the world. Mycoplasma pneumoniae (MP) was one of the likely causative agents of KD. However, the etiologic effect of MP in KD has not been fully recognized.
We prospectively analyzed the clinical records of 450 patients with KD hospitalized in Children's Hospital of Soochow University from 2012 to 2014. Using medical records, we retrospectively identified patients with low respiratory tract infection (non-KD group).
Of the 450 KD patients, MP was positive in 62 (13.8 %). The median age of the MP + KD+ group was significantly older than the MP-KD+ group (25 vs 14.5 months, P < 0.01). MP + KD+ group had higher levels of ESR, N% and CRP than the MP-KD+ group. MP + KD+ group were more frequent in respiratory disorders than MP-KD+ group with a P < 0.05. No statistical difference of non-responders or coronary artery lesion was found between the groups.
MP infections are found in an important proportion of the KD patients (13.8 % in our series). MP infection tended to occur in older populations and with a higher rate of respiratory tract involvement in patients with KD. No statistical difference of non-responders or coronary artery lesion was found between the MP+ and MP- KD patients.
川崎病（KD）是一种病因不明的疾病，主要发生于5岁以下儿童，是全球后天性心脏病的主要病因。肺炎支原体（MP）是KD可能的致病因素之一。然而，MP在KD中的病因学作用尚未得到充分认识。
我们前瞻性分析了2012年至2014年在苏州大学附属儿童医院住院的450例KD患者的临床记录。利用病历，我们回顾性确定了下呼吸道感染患者（非KD组）。
450例KD患者中，62例（13.8%）MP呈阳性。MP+KD+组的中位年龄显著大于MP-KD+组（25个月对14.5个月，P<0.01）。MP+KD+组的血沉、中性粒细胞百分比和C反应蛋白水平高于MP-KD+组。MP+KD+组的呼吸道疾病发生率高于MP-KD+组，P<0.05。两组间无反应者或冠状动脉病变无统计学差异。
在相当比例的KD患者中发现MP感染（我们系列中为13.8%）。MP感染倾向于发生在年龄较大的人群中，且KD患者呼吸道受累率较高。MP+和MP-KD患者之间无反应者或冠状动脉病变无统计学差异。
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