Stachura Joanna, Wachowska Malgorzata, Kilarski Witold W, Güç Esra, Golab Jakub, Muchowicz Angelika
Department of Immunology, Medical University of Warsaw, Warsaw, Poland; Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Department of Immunology, Medical University of Warsaw, Warsaw, Poland; Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
Oncoimmunology. 2016 May 13;5(7):e1182278. doi: 10.1080/2162402X.2016.1182278. eCollection 2016 Jul.
Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT).
淋巴脉管系统在免疫反应中起着至关重要的作用，能够将树突状细胞（DCs）和抗原（Ags）输送到淋巴结。不幸的是，淋巴系统在癌症疾病进展中也具有负面作用，它会促使许多 carcinomas 转移至引流淋巴结。淋巴管既能促进抗肿瘤免疫反应，也能导致肿瘤耐受。在此，我们综述了淋巴管内皮细胞（LECs）在肿瘤进展和免疫中的作用，以及最新抗淋巴治疗（包括光动力疗法（PDT））的作用机制。
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