[1例经荧光原位杂交（FISH）诊断的Xp.11.2易位性肾细胞癌]

[A Case of Xp.11.2 Traslocational Renal Cell Carcinoma Diagnosed by Fluorescence in Situ Hybridization (FISH)].

作者信息

Iinuma Koji, Kojima Keitaro, Okamoto Kiyohisa, Yuhara Kazuya

机构信息

The Department of Urology, Japanese Red Cross Takayama Hospital.

The Department of Surgical Pathology, Japanese Red Cross Takayama Hospital.

出版信息

Hinyokika Kiyo. 2016 Aug;62(8):411-4. doi: 10.14989/ActaUrolJap_62_8_411.

DOI:10.14989/ActaUrolJap_62_8_411

PMID:27624107

Abstract

A 72-year-old woman was referred to our hospital with complaints of macro-hematuria. The radiographic evaluation including computed tomography (CT) and magnetic resonance imaging (MRI) suggested it to be renal cell carcinoma (RCC) in her right kidney. She underwent laparoscopic nephrectomy. We diagnosed her with renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion, based on pathological findings and break apart of transcription factor E3 (TFE3)by fluorescence in situ hybridization. She was free of recurrence at 8 months postoperatively.

摘要

一名72岁女性因肉眼血尿前来我院就诊。包括计算机断层扫描（CT）和磁共振成像（MRI）在内的影像学评估提示其右肾患有肾细胞癌（RCC）。她接受了腹腔镜肾切除术。根据病理结果以及荧光原位杂交显示的转录因子E3（TFE3）分离情况，我们诊断她为伴有Xp11.2易位/TFE3基因融合的肾细胞癌。术后8个月她未出现复发。