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肉毒杆菌毒素A治疗后间歇性系列石膏固定对脑瘫患儿痉挛性马蹄足疗效的随机对照试验

Randomized Controlled Trial on Effectiveness of Intermittent Serial Casting on Spastic Equinus Foot in Children with Cerebral Palsy After Botulinum Toxin-A Treatment.

作者信息

Dursun Nigar, Gokbel Tugba, Akarsu Melike, Dursun Erbil

机构信息

From the Department of Physical Medicine and Rehabilitation, Kocaeli University, Kocaeli, Turkey.

出版信息

Am J Phys Med Rehabil. 2017 Apr;96(4):221-225. doi: 10.1097/PHM.0000000000000627.

Abstract

OBJECTIVE

Physical therapy (PT) and botulinum toxin-A (BTX-A) injections are widely used in the treatment of spastic equinus foot due to cerebral palsy. The aim of this study was to show effects of intermittent serial casting (SC) in addition to standard treatment on spasticity, passive range of motion (PROM), and gait.

DESIGN

Fifty-one ambulatory patients, treated by BTX-A to plantar flexor muscles, were randomly assigned to casting or control groups in a 2:1 ratio. Both groups received PT for 3 weeks. Casting group additionally received intermittent SC during 3 consecutive weekends. Assessments included Modified Ashworth Scale (MAS), Tardieu Scale, Observational Gait Scale (OGS), and Physician Global Assessment at baseline and posttreatment weeks 4 and 12.

RESULTS

Significant improvements in PROM, MAS, Tardieu Scale, and OGS were recorded in both groups (P < 0.001 for all). Average changes in MAS, PROM, angle of catch, spasticity angle, and OGS of the casting group were significantly higher than those of the controls at week 4 (P = 0.006, P = 0.002, P < 0.001, P = 0.005, P = 0.011), and 12 (P = 0.013, P < 0.001, P < 0.001, P = 0.011, P < 0.001). Follow-up Physician Global Assessment also favored casting group (P < 0.001 for both).

CONCLUSIONS

Combining intermittent SC with BTX-A injections and PT might provide additional benefits for spastic equinus foot.

TO CLAIM CME CREDITS

Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME OBJECTIVES: Upon completion of this article, the reader should be able to: (1) identify treatment options for spastic equinus goot in children with cerebral palsy; (2) explain different approaches of serial casting with an additional model of intermittent casting; and (3) describe the potential benefits of combined treatment modalities, including intermittent serial casting, for spastic equinus foot in children with cerebral palsy.

LEVEL

Advanced ACCREDITATION: The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.The Association of Academic Physiatrists designates this activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

摘要

目的

物理治疗(PT)和肉毒杆菌毒素A(BTX - A)注射广泛用于治疗脑瘫所致的痉挛性马蹄足。本研究的目的是显示在标准治疗基础上间歇性连续石膏固定(SC)对痉挛、被动活动范围(PROM)和步态的影响。

设计

51例接受BTX - A注射至足底屈肌的门诊患者,以2:1的比例随机分为石膏固定组或对照组。两组均接受3周的PT治疗。石膏固定组在连续3个周末额外接受间歇性SC治疗。评估包括改良Ashworth量表(MAS)、Tardieu量表、观察步态量表(OGS),以及在基线、治疗后第4周和第12周的医生整体评估。

结果

两组的PROM、MAS、Tardieu量表和OGS均有显著改善(所有P < 0.001)。在第4周(P = 0.006、P = 0.002、P < 0.001、P = 0.005、P = 0.011)和第12周(P = 0.013、P < 0.001、P < 0.001、P = 0.011、P < 0.001)时,石膏固定组的MAS、PROM、牵张角、痉挛角和OGS的平均变化显著高于对照组。随访的医生整体评估也更倾向于石膏固定组(两者P < 0.001)。

结论

将间歇性SC与BTX - A注射及PT相结合可能对痉挛性马蹄足有额外益处。

申请继续医学教育学分

http://www.physiatry.org/JournalCME在线完成自我评估活动和评价。继续医学教育目标:阅读本文后,读者应能够:(1)确定脑瘫患儿痉挛性马蹄足的治疗选择;(2)解释连续石膏固定的不同方法及间歇性石膏固定的额外模式;(3)描述联合治疗方式(包括间歇性连续石膏固定)对脑瘫患儿痉挛性马蹄足的潜在益处。

级别

高级。认证:学术物理医学与康复医师协会经继续医学教育认证委员会认可,可为医生提供继续医学教育。学术物理医学与康复医师协会将此活动指定为最多1.5个美国医学协会(AMA)PRA第1类学分™。医生应仅根据其参与活动的程度申请相应学分。

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