[刚果民主共和国卢本巴希五岁以下儿童、学龄儿童无症状寄生虫血症及家庭自我药疗]

[Asymptomatic Parasitemia in under five, school age children and households self-medication, Lubumbashi, Democratic Republic of Congo].

作者信息

Mukomena Sompwe Eric, Philipe Cilundika Mulenga, Désiré Mashinda Kulimba, Pascal Lutumba Tshindele, Ali Mapatano Mala, Oscar Luboya Numbi

机构信息

Département de Santé Publique, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo; Ecole de Santé Publique, Université de Lubumbashi, République Démocratique du Congo.

Département de Santé Publique, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.

出版信息

Pan Afr Med J. 2016 May 27;24:94. doi: 10.11604/pamj.2016.24.94.9350. eCollection 2016.

DOI:10.11604/pamj.2016.24.94.9350

PMID:27642433

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5012784/

Abstract

INTRODUCTION

Long neglected, asymptomatic malaria is currently recognized as a potential threat and obstacle to malaria control. In DR Congo, the prevalence of this parasite is poorly documented. This study aims to determine the prevalence of asymptomatic parasitaemia in children less than 5 years of age as well as in those aged over five years for what concerns ongoing mass control interventions (LLINs).

METHODS

This is a cross-sectional study conducted among school age children, children less than 5 years of age living in the household of Lubumbashi. Schools, students and children less than 5 years of age were selected randomly. Thick and thin blood smears and rapid tests were performed and read.

RESULTS

Out of 350 examined students, 43 (12, 3%), IC 95% (9, 14-16, 04) had positive thick smear. Only plasmodium falciparum was identified in all the 43 cases. 314 households (90.5%) declared that they had administered anti-malarial drugs to their children to treat fever at home. More than one-third of households (39.9%) declared that they had administered antipyretics to their children to relieve fever, 19.7% administered quinine and only less than 2% artemether-lumefantrine. Considering the use of the TDR technique, the prevalence of asymptomatic parasitaemia was 3%, IC 95% (from 2.075 to 4.44), but if we consider microscopy as the gold standard, the prevalence was 1.9%, IC 95% (from 1.13 to 3.01).

CONCLUSION

Asymptomatic malaria is not without health consequences, so it is important to conduct such investigations to detect new malaria device programmes.

摘要

引言

长期被忽视的无症状疟疾目前被认为是疟疾控制的潜在威胁和障碍。在刚果民主共和国，这种寄生虫的流行情况记录不足。本研究旨在确定5岁以下儿童以及5岁以上儿童中无症状寄生虫血症的流行情况，涉及正在进行的大规模控制干预措施（长效驱虫蚊帐）。

方法

这是一项在学龄儿童、居住在卢本巴希家庭中的5岁以下儿童中进行的横断面研究。学校、学生和5岁以下儿童均随机选取。进行并读取厚血膜和薄血膜涂片以及快速检测。

结果

在350名接受检查的学生中，43名（12.3%），95%置信区间（9.14 - 16.04）厚血膜涂片呈阳性。在所有43例病例中仅鉴定出恶性疟原虫。314户家庭（90.5%）宣称他们曾在家中给孩子服用抗疟药物治疗发烧。超过三分之一的家庭（39.9%）宣称他们曾给孩子服用退烧药缓解发烧，19.7%的家庭服用了奎宁，而服用蒿甲醚 - 本芴醇的家庭不到2%。考虑到使用TDR技术，无症状寄生虫血症的流行率为3%，95%置信区间（2.075至4.44），但如果我们将显微镜检查视为金标准，流行率为1.9%，95%置信区间（1.13至3.01）。