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伯尔尼髋臼周围截骨术后发育不良的影像学参数会改善至正常范围吗?

Do Radiographic Parameters of Dysplasia Improve to Normal Ranges After Bernese Periacetabular Osteotomy?

作者信息

Novais Eduardo N, Duncan Stephen, Nepple Jeffrey, Pashos Gail, Schoenecker Perry L, Clohisy John C

机构信息

Department of Orthopedic Surgery, Boston Children's Hospital, Boston, MA, USA.

Department of Orthopedic Surgery, University of Kentucky, Lexington, KY, USA.

出版信息

Clin Orthop Relat Res. 2017 Apr;475(4):1120-1127. doi: 10.1007/s11999-016-5077-8.

Abstract

BACKGROUND

The goal of periacetabular osteotomy (PAO) is to improve the insufficient coverage of the femoral head and achieve joint stability without creating secondary femoroacetabular impingement. However, the complex tridimensional morphology of the dysplastic acetabulum presents a challenge to restoration of normal radiographic parameters. Accurate acetabular correction is important to achieve long-term function and pain improvement. There are limited data about the proportion of patients who have normal radiographic parameters restored after PAO and the factors associated with under- and overcorrection.

QUESTIONS/PURPOSES: (1) What is the proportion of patients undergoing PAO in which the acetabular correction as assessed by the lateral center-edge angle (LCEA), anterior center-edge angle (ACEA), acetabular inclination (AI), and extrusion index (EI) is within defined target ranges? (2) What patient and preoperative factors are associated with undercorrection of the acetabulum as defined by a LCEA < 22°, a factor that has been reported to be associated with PAO failure at 10-year followup?

METHODS

Between January 2007 and December 2011 we performed 132 PAOs in 116 patients for treatment of symptomatic acetabular dysplasia. One patient with Legg-Calvé-Perthes disease, one with multiple osteochondromatosis, and two with concomitant femoral osteotomy were excluded. A total of 128 hips (112 patients) were included. The hip cohort was 76% (97 of 128) female and the mean age at surgery was 28.5 years (SD 8.7 years). Correction of LCEA between 25° and 40°, ACEA between 18° and 38°, Tönnis angle between 0° and 10°, and EI ≤ 20% were defined as adequate based on normative values. Values lower than the established parameters were considered undercorrection for the LCEA and ACEA and those higher than the established values were considered overcorrection. Because postoperative LCEA < 22 has been previously associated with PAO failure at a minimum of 10-year followup, in this study we sought to measure whether demographic factors including age, gender, body mass index, and severity of acetabular dysplasia assessed by preoperative LCEA, ACEA, AI, and EI were associated with undercorrection. Postoperative radiographs were obtained at minimum of 1 month after surgery (mean, 7 months; range, 1-44 months) and were measured by a professional research assistant and a hip reconstruction fellow not involved in the clinical care of the patients. No patient was lost to followup.

RESULTS

Of the 128 hips, the proportion of hips with radiographic parameters within the established range was 78% (100 hips) for the LCEA, 86% (110 hips) for the ACEA, 89% (114 hips) for the AI, and 80% (102 hips) for the EI. For hips with an inadequate correction, the LCEA was more often undercorrected than overcorrected (20% versus 2%; 95% confidence interval [CI], 11%-27%; p < 0.001), whereas the ACEA was more often overcorrected than undercorrected (11% versus 3%; 95% CI, 1%-15%; p = 0.03) After adjusting for age, sex, body mass index, and preoperative radiographic parameters including ACEA, AI, and EI, we found that the preoperative LCEA was the only independent factor associated with a postoperative LCEA < 22° (odds ratio, 0.92; 95% CI, 0.87-0.97; p = 0.003), indicating that hips with lower preoperative LCEA were more likely to have a LCEA < 22°. For each additional degree of preoperative LCEA, the odds of LCEA < 22° were reduced by 15%.

CONCLUSIONS

Acetabular correction after PAO performed by two experienced surgeons was adequate for individual radiographic parameters in most but not all hips. Hips with more severe dysplasia preoperatively are at higher risk for undercorrection as assessed by the LCEA. This intuitive information may help surgeons performing PAO in severely dysplastic hips plan for possible combined procedures including a femoral osteotomy if PAO alone does not allow for adequate correction of femoral head coverage and a congruous concentric hip. Further studies are planned to determine whether the long-term hip function and pain in patients whose hips were corrected within these established parameters will be improved in comparison to those that were under- or overcorrected.

LEVEL OF EVIDENCE

Level III, therapeutic study.

摘要

背景

髋臼周围截骨术(PAO)的目标是改善股骨头覆盖不足并实现关节稳定,同时不产生继发性股骨髋臼撞击。然而,发育不良髋臼的复杂三维形态对恢复正常影像学参数构成挑战。准确的髋臼矫正对于实现长期功能和缓解疼痛很重要。关于PAO术后恢复正常影像学参数的患者比例以及与矫正不足和过度矫正相关的因素的数据有限。

问题/目的:(1)接受PAO治疗的患者中,通过外侧中心边缘角(LCEA)、前侧中心边缘角(ACEA)、髋臼倾斜度(AI)和挤压指数(EI)评估的髋臼矫正处于定义的目标范围内的比例是多少?(2)哪些患者和术前因素与髋臼矫正不足相关,髋臼矫正不足定义为LCEA < 22°,据报道该因素与10年随访时PAO失败相关?

方法

2007年1月至2011年12月期间,我们对116例患者进行了132次PAO手术,以治疗有症状的髋臼发育不良。排除1例患有Legg-Calvé-Perthes病的患者、1例患有多发性骨软骨瘤病的患者以及2例同时进行股骨截骨术的患者。共纳入128髋(112例患者)。该髋部队列中女性占76%(128例中的97例),手术时的平均年龄为28.5岁(标准差8.7岁)。根据正常数值,将LCEA矫正至25°至40°、ACEA矫正至18°至38°、Tönnis角矫正至0°至10°以及EI≤20%定义为充分矫正。低于既定参数的值被认为是LCEA和ACEA矫正不足,高于既定值的值被认为是过度矫正。由于术后LCEA < 22°先前已被证明与至少10年随访时的PAO失败相关,在本研究中,我们试图测量包括年龄、性别、体重指数以及通过术前LCEA、ACEA、AI和EI评估的髋臼发育不良严重程度等人口统计学因素是否与矫正不足相关。术后X线片在术后至少1个月时获取(平均7个月;范围1 - 44个月),由一名专业研究助理和一名未参与患者临床护理的髋关节重建研究员进行测量。没有患者失访。

结果

在128髋中,LCEA影像学参数在既定范围内的髋部比例为78%(100髋),ACEA为86%(110髋),AI为89%(114髋),EI为80%(102髋)。对于矫正不足的髋部,LCEA矫正不足的情况比过度矫正更常见(20%对2%;置信区间[CI],11% - 27%;p < 0.001),而ACEA过度矫正的情况比矫正不足更常见(11%对3%;95% CI,1% - 15%;p = 0.03)。在对年龄、性别、体重指数以及包括ACEA、AI和EI在内的术前影像学参数进行调整后,我们发现术前LCEA是与术后LCEA < 22°相关的唯一独立因素(优势比,0.92;95% CI,0.87 - 0.97;p = 0.003),这表明术前LCEA较低的髋部更有可能出现LCEA < 22°。术前LCEA每增加1度,LCEA < 22° 的几率降低15%。

结论

由两名经验丰富的外科医生进行的PAO术后髋臼矫正对于大多数但并非所有髋部的个体影像学参数是充分的。术前发育不良更严重的髋部,根据LCEA评估,矫正不足的风险更高。这一直观信息可能有助于在严重发育不良的髋部进行PAO手术的外科医生规划可能的联合手术,包括如果单独的PAO不能充分矫正股骨头覆盖和实现一致的同心髋关节,则进行股骨截骨术。计划进一步研究以确定与矫正不足或过度矫正的患者相比,在这些既定参数范围内矫正的患者的长期髋关节功能和疼痛是否会得到改善。

证据水平

III级,治疗性研究。

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