胞质磺基转移酶（SULTs）及SULT介导的硫酸化作用的最新观点
Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation.
作者信息
Suiko Masahito, Kurogi Katsuhisa, Hashiguchi Takuyu, Sakakibara Yoichi, Liu Ming-Cheh
机构信息
a Faculty of Agriculture, Department of Biochemistry and Applied Biosciences , University of Miyazaki , Miyazaki , Japan.
b Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences , University of Toledo Health Science Campus , Toledo , OH , USA.
出版信息
Biosci Biotechnol Biochem. 2017 Jan;81(1):63-72. doi: 10.1080/09168451.2016.1222266. Epub 2016 Sep 21.
The cytosolic sulfotransferases (SULTs) are Phase II detoxifying enzymes that mediate the sulfate conjugation of numerous xenobiotic molecules. While the research on the SULTs has lagged behind the research on Phase I cytochrome P-450 enzymes and other Phase II conjugating enzymes, it has gained more momentum in recent years. This review aims to summarize information obtained in several fronts of the research on the SULTs, including the range of the SULTs in different life forms, concerted actions of the SULTs and other Phase II enzymes, insights into the structure-function relationships of the SULTs, regulation of SULT expression and activity, developmental expression of SULTs, as well as the use of a zebrafish model for studying the developmental pharmacology/toxicology.
胞质磺基转移酶（SULTs）是II相解毒酶，可介导多种外源性分子的硫酸化结合反应。虽然对SULTs的研究落后于对I相细胞色素P-450酶和其他II相结合酶的研究，但近年来其研究势头有所增强。本综述旨在总结SULTs研究多个方面所获得的信息，包括不同生命形式中SULTs的范围、SULTs与其他II相酶的协同作用、对SULTs结构-功能关系的认识、SULT表达和活性的调节、SULTs的发育表达，以及利用斑马鱼模型研究发育药理学/毒理学。
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