抵抗素和瘦素在预测急性胰腺炎患者持续性器官功能衰竭中的作用
Efficacy of resistin and leptin in predicting persistent organ failure in patients with acute pancreatitis.
作者信息
Yu Pengfei, Wang Shiqi, Qiu Zhaoyan, Bai Bin, Zhao Zhanwei, Hao Yiming, Wang Qian, Guo Min, Feng Xiangying, Zhu Junjie, Feng Quanxin, Zhao Qingchuan
机构信息
State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China; Department of General Surgery, The General Hospital of People' Liberation Army (301 Hospital), 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
出版信息
Pancreatology. 2016 Nov-Dec;16(6):952-957. doi: 10.1016/j.pan.2016.09.002. Epub 2016 Sep 7.
BACKGROUND
To investigate the accuracy of resistin, leptin and adiponectin levels in predicting persistent organ failure in patients with acute pancreatitis (AP).
METHODS
Data from 90 consecutive patients admitted to our hospital for AP were retrospectively collected from an ongoing prospective cohort study. The levels of adiponectin, leptin and resistin were measured and compared between patients with and without persistent organ failure. The accuracy of the adipokines in predicting persistent organ failure were compared with the patients' Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, and were separately investigated in overweight and non-overweight groups.
RESULTS
Persistent organ failure occurred in 26.7% of the patients. The levels of resistin were significantly increased in AP patients with persistent organ failure, in both the overweight and the non-overweight subgroups. Resistin and APACHE-II score predicted persistent organ failure with comparable areas under the curve (AUC) of 0.72 and 0.75, respectively (p = 0.66). Resistin demonstrated similar accuracy with the APACHE-II score in predicting persistent organ failure in the overweight (0.69 vs. 0.66, p = 0.82) and non-overweight (0.76 vs. 0.87, p = 0.39) subgroups. There was no correlation between adiponectin and persistent organ failure, but a weak correlation between leptin and persistent organ failure was demonstrated.
CONCLUSIONS
Resistin and leptin levels, rather than adiponectin, correlate with persistent organ failure in patients with AP.
背景
探讨抵抗素、瘦素和脂联素水平预测急性胰腺炎（AP）患者持续性器官衰竭的准确性。
方法
从一项正在进行的前瞻性队列研究中回顾性收集我院收治的90例连续AP患者的数据。测量并比较发生和未发生持续性器官衰竭患者的脂联素、瘦素和抵抗素水平。将这些脂肪因子预测持续性器官衰竭的准确性与患者的急性生理与慢性健康状况评分系统II（APACHE-II）评分进行比较，并分别在超重和非超重组中进行研究。
结果
26.7%的患者发生了持续性器官衰竭。在超重和非超重亚组中，发生持续性器官衰竭的AP患者抵抗素水平均显著升高。抵抗素和APACHE-II评分预测持续性器官衰竭的曲线下面积（AUC）分别为0.72和0.75，具有可比性（p = 0.66）。在超重（0.69对0.66，p = 0.82）和非超重（0.76对0.87，p = 0.39）亚组中，抵抗素在预测持续性器官衰竭方面与APACHE-II评分具有相似的准确性。脂联素与持续性器官衰竭之间无相关性，但瘦素与持续性器官衰竭之间存在弱相关性。
结论
AP患者中，与持续性器官衰竭相关的是抵抗素和瘦素水平，而非脂联素水平。
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