基质金属蛋白酶-1启动子多态性与接受放疗的肺癌患者发生放射性肺损伤的风险相关。
MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.
作者信息
Liu Bo, Yi Minxiao, Tang Yang, Liu Qingxu, Qiu Hong, Zou Yanmei, Peng Ping, Zhang Lu, Hu Chunping, Yuan Xianglin
机构信息
Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Department of Statistics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
出版信息
Oncotarget. 2016 Oct 25;7(43):70175-70184. doi: 10.18632/oncotarget.12164.
Matrix metalloproteinase-1 (MMP-1) has been implicated in several inflammatory and fibrotic diseases. We hypothesized that genetic variations in the MMP1 promoter region are associated with risk of radiation-induced lung injury (RILI). A cohort of 251 lung cancer patients was genotyped for five single nucleotide polymorphisms in the MMP1 promoter region. We found that rs1144393 AG/GG was strongly correlated with an increased occurrence of grade ≥ 2 RILI (p = 0.002). Additionally, patients with the rs1144393 AG/GG genotypes exhibited higher MMP-1 expression than patients with the AA genotype in lung tissues (n = 28, p = 0.022) and plasma samples (n = 40, p = 0.018). Our results indicated that rs1144393 in the MMP1 promoter region can be a predictor of grade ≥ 2 RILI in lung cancer patients treated with thoracic radiation.
基质金属蛋白酶-1（MMP-1）与多种炎症和纤维化疾病有关。我们假设MMP1启动子区域的基因变异与放射性肺损伤（RILI）的风险相关。对一组251例肺癌患者的MMP1启动子区域的五个单核苷酸多态性进行基因分型。我们发现rs1144393 AG/GG与2级及以上RILI发生率增加密切相关（p = 0.002）。此外，rs1144393 AG/GG基因型的患者在肺组织（n = 28，p = 0.022）和血浆样本（n = 40，p = 0.018）中比AA基因型的患者表现出更高的MMP-1表达。我们的结果表明，MMP1启动子区域的rs1144393可以作为接受胸部放疗的肺癌患者2级及以上RILI的预测指标。
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