Tabei Ken-Ichi, Satoh Masayuki, Nakano Chizuru, Ito Ai, Shimoji Yasuo, Kida Hirotaka, Sakuma Hajime, Tomimoto Hidekazu
Department of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan; Department of Neurology, Graduate School of Medicine, Mie University, Mie, Japan.
Department of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University , Mie , Japan.
Front Neurol. 2016 Sep 19;7:148. doi: 10.3389/fneur.2016.00148. eCollection 2016.
Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive 9-day training on the Japanese version of MIT (MIT-J). The purpose of this study was to verify the efficacy of MIT-J by functional assessment and examine associated changes in neural processing by functional magnetic resonance imaging. MIT improved language output and auditory comprehension, and decreased the response time for picture naming. Following MIT-J, an area of the right hemisphere was less activated on correct naming trials than compared with before training but similarly activated on incorrect trials. These results suggest that the aphasic symptoms of our patient were improved by increased neural processing efficiency and a concomitant decrease in cognitive load.
旋律语调疗法（MIT）是一种针对有言语产生障碍的失语症患者进行康复治疗的方案。我们报告了一例严重慢性非流利性失语症患者，该患者对多年的传统治疗无反应，但在接受了为期9天的日语版MIT（MIT-J）强化训练后有显著改善。本研究的目的是通过功能评估验证MIT-J的疗效，并通过功能磁共振成像检查神经加工过程中的相关变化。MIT改善了语言输出和听觉理解能力，并缩短了图片命名的反应时间。接受MIT-J训练后，与训练前相比，在正确命名试验中右半球的一个区域激活程度降低，但在错误试验中激活程度相似。这些结果表明，我们的患者失语症状的改善是由于神经加工效率提高以及认知负荷相应降低。
