二氢槲皮素不影响高血压大鼠主动脉中随年龄增长的血压升高和血管紧张素转换酶活性。

Dihydroquercetin Does Not Affect Age-Dependent Increase in Blood Pressure and Angiotensin-Converting Enzyme Activity in the Aorta of Hypertensive Rats.

作者信息

Slashcheva G A, Rykov V A, Lobanov A V, Murashev A N, Kim Yu A, Arutyunyan T V, Korystova A F, Kublik L N, Levitman M Kh, Shaposhnikona V V, Korystov Yu N

机构信息

Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.

Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia.

出版信息

Bull Exp Biol Med. 2016 Sep;161(5):670-673. doi: 10.1007/s10517-016-3482-3. Epub 2016 Oct 5.

DOI:10.1007/s10517-016-3482-3

PMID:27709387

Abstract

We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme. Thus, the early (7-14 weeks) increase in BP and angiotensin-converting enzyme activity in the aorta of SHR rats was not modified by flavonoids (dihydroquercetin) in contrast to other rat strains and humans, which is indicative of specificity of hypertension mechanism in SHR rats.

摘要

我们分析了高血压SHR大鼠主动脉中血管紧张素转换酶活性在与年龄相关的血压升高背景下（从第7周到第14周）的变化，以及二氢槲皮素对血压升高和血管紧张素转换酶活性的影响。将相同年龄的正常血压WKY大鼠用作对照。SHR大鼠主动脉中的血压和血管紧张素转换酶活性随年龄增加。每天100和300μg/kg剂量的二氢槲皮素对这些参数的增加没有影响；以300μg/kg的剂量给14周龄的WKY大鼠施用二氢槲皮素可降低血管紧张素转换酶的活性。因此，与其他大鼠品系和人类不同，SHR大鼠主动脉中血压和血管紧张素转换酶活性的早期（7 - 14周）升高未被类黄酮（二氢槲皮素）改变，这表明SHR大鼠高血压机制具有特异性。