新生儿非甾体抗炎药的肾脏副作用
Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates.
作者信息
Allegaert Karel, De Hoon Jan, Debeer Anne, Gewillig Marc
机构信息
Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
Center for Clinical Pharmacology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
出版信息
Pharmaceuticals (Basel). 2010 Feb 3;3(2):393-405. doi: 10.3390/ph3020393.
Non-steroidal anti-inflammatory drugs like ibuprofen or indomethacin are commonly prescribed drugs to induce pharmacologic closure of a patent ductus arteriosus in preterm neonates. Based on a recently published Cochrane meta-analysis, both drugs are equally effective to induce closure. Drug choice can therefore be based on differences in side effects or pharmaco-economic arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiable impact on renal function. However, compared to ibuprofen, the negative impact of indomethacin is more pronounced.
布洛芬或吲哚美辛等非甾体类抗炎药是常用于诱导早产儿动脉导管未闭药物性闭合的药物。根据最近发表的一项Cochrane荟萃分析，这两种药物在诱导闭合方面同样有效。因此，药物选择可以基于副作用差异或药物经济学考量。本综述量化了布洛芬或吲哚美辛对肾功能的负面影响，包括利尿、肾小球滤过率和肾小管功能。布洛芬和吲哚美辛对肾功能均有可量化的影响。然而，与布洛芬相比，吲哚美辛的负面影响更为明显。
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