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[各种增加腹膜透析有效性的药理学和传统方法的比较。V. 腹膜转运选定参数对评估间歇性腹膜透析有效性的有用性]

[Comparison of various pharmacologic and conventional methods of increasing the effectiveness of peritoneal dialysis. V. Usefulness of selected parameters of peritoneal transfer for evaluating the effectiveness of intermittent peritoneal dialysis].

作者信息

Grzegorzewska A

出版信息

Przegl Lek. 1989;46(5):440-7.

PMID:2772244
Abstract

On the basis of analysis of peritoneal transfer parameters in intermittent++ peritoneal dialysis it was shown that 1) dialysate/plasma ratio is a good parameter for comparison of efficiency of peritoneal dialyses performed using different schedule only when dialysis fluid flow rate is unchanged; 2) dialysis-induced ultrafiltration markedly influences peritoneal transfer parameters of sodium; 3) when the influence of residual dialysis fluid on peritoneal transfer parameters is excluded, peritoneal clearance is very useful in comparison of efficiency of peritoneal dialyses performed using different dialysis schedule, but if dialysis schedule is changed during the course of dialysis, the determination of clearance value in each exchange is advisable because dialysis schedule used in one dialysis period can influence clearance value in following exchanges performed in different manner; 4) concentration of low-molecular-weight substances in dialysate after intraperitoneal administration of pharmacological agent if does not decrease in the course of dialysis may indicate on enhancing effect of this agent on peritoneal transfer.

摘要

基于对间歇性腹膜透析中腹膜转运参数的分析表明

1)仅当透析液流速不变时,透析液/血浆比率才是比较采用不同方案进行腹膜透析效率的良好参数;2)透析诱导的超滤对钠的腹膜转运参数有显著影响;3)排除残留透析液对腹膜转运参数的影响后,腹膜清除率在比较采用不同透析方案进行腹膜透析的效率时非常有用,但如果在透析过程中改变透析方案,建议测定每次交换的清除率值,因为一个透析周期中使用的透析方案可能会影响以不同方式进行的后续交换的清除率值;4)腹腔内给予药理剂后,如果透析过程中透析液中低分子量物质的浓度不降低,则可能表明该药剂对腹膜转运有增强作用。

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