Bibi Fehmida, Faheem Muhammad, Azhar Esam I, Yasir Muhammad, Alvi Sana A, Kamal Mohammad A, Ullah Ikram, Naseer Muhammad I
Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University Jeddah 21589, Saudi Arabia.
Curr Drug Metab. 2017;18(1):11-15. doi: 10.2174/1389200217666161013090610.
Sponges are rich source of bioactive natural products synthesized by the symbiotic bacteria belonging to different phyla. Due to a competition for space and nutrients the marine bacteria associated with sponges could produce more antibiotic substances. To explore the proactive potential of marine microbes extensive research has been done. These bioactive metabolites have some unique properties that are pharmaceutically important.
For this review, we have performed a non-systematic search of the available literature though various online search engines. This review provides an insight that how majority of active metabolites have been identified from marine invertebrates of which sponges predominate.
Sponges harbor abundant and diverse microorganisms, which are the sources of a range of marine bioactive metabolites. From sponges and their associated microorganisms, approximately 5,300 different natural compounds are known. Current research on sponge-microbe interaction and their active metabolites has become a focal point for many researchers. Various active metabolites derived from sponges are now known to be produced by their symbiotic microflora.
In this review, we attempt to report the latest studies regarding capability of bacteria from sponges as producers of bioactive metabolite. Moreover, these sponge associated bacteria are an important source of different enzymes of industrial significance. In present review, we will address some novel approaches for discovering marine metabolites from bacteria that have the greatest potential to be used in clinical treatments.
海绵是由属于不同门类的共生细菌合成的生物活性天然产物的丰富来源。由于对空间和营养的竞争，与海绵相关的海洋细菌可能会产生更多的抗生素物质。为了探索海洋微生物的积极潜力，已经进行了广泛的研究。这些生物活性代谢物具有一些在药学上很重要的独特性质。
在本次综述中，我们通过各种在线搜索引擎对现有文献进行了非系统性检索。本综述深入探讨了如何从海洋无脊椎动物中鉴定出大多数活性代谢物，其中海绵占主导地位。
海绵中含有丰富多样的微生物，它们是一系列海洋生物活性代谢物的来源。已知从海绵及其相关微生物中可提取出约5300种不同的天然化合物。目前关于海绵 - 微生物相互作用及其活性代谢物的研究已成为许多研究人员的焦点。现在已知海绵衍生的各种活性代谢物是由其共生微生物群落产生的。
在本综述中，我们试图报告关于海绵细菌作为生物活性代谢物生产者能力的最新研究。此外，这些与海绵相关的细菌是具有工业意义的不同酶的重要来源。在本综述中，我们将探讨一些从细菌中发现海洋代谢物的新方法，这些细菌在临床治疗中具有最大的应用潜力。
