Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, 9300 Campus Point Drive, # 7745 La Jolla, CA 92037-1300, USA.
Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, 9300 Campus Point Drive, # 7745 La Jolla, CA 92037-1300, USA.
Clin Liver Dis. 2016 Nov;20(4):703-720. doi: 10.1016/j.cld.2016.06.007. Epub 2016 Aug 9.
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, and its incidence has been increasing in the last decade largely in parallel to the incidence and duration of exposure to hepatitis B and C. The widespread implementation of hepatitis B vaccine, hepatitis B antivirals, and the introduction of direct antiviral therapies for hepatitis C virus may have a substantial impact in reducing the incidence of HCC. This report reviews the risk factors and underlying mechanisms associated with the development of HCC in hepatitis B, along with advances in the diagnosis, imaging, and management of HCC.
肝细胞癌（HCC）是全球癌症死亡的主要原因之一，在过去十年中，其发病率与乙型肝炎和丙型肝炎的发病率和持续时间呈平行上升趋势。乙型肝炎疫苗、乙型肝炎抗病毒药物的广泛应用以及丙型肝炎病毒直接抗病毒治疗方法的引入可能会对降低 HCC 的发病率产生重大影响。本报告回顾了乙型肝炎相关 HCC 发展的危险因素和潜在机制，以及 HCC 的诊断、影像学和治疗进展。
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