Division of Women's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Lancet Diabetes Endocrinol. 2016 Dec;4(12):1025-1036. doi: 10.1016/S2213-8587(16)30217-0. Epub 2016 Oct 12.
Obesity in women of reproductive age is increasing in prevelance worldwide. Obesity reduces fertility and increases time taken to conceive, and obesity-related comorbidities (such as type 2 diabetes and chronic hypertension) heighten the risk of adverse outcomes for mother and child if the woman becomes pregnant. Pregnant women who are obese are more likely to have early pregnancy loss, and have increased risk of congenital fetal malformations, delivery of large for gestational age infants, shoulder dystocia, spontaneous and medically indicated premature birth, and stillbirth. Late pregnancy complications include gestational diabetes and pre-eclampsia, both of which are associated with long-term morbidities post partum. Women with obesity can also experience difficulties during labour and delivery, and are more at risk of post-partum haemorrhage. Long-term health risks are associated with weight retention after delivery, and inherent complications for the next pregnancy. The wellbeing of the next generation is also compromised. All these health issues could be avoided by prevention of obesity among women of reproductive age, which should be viewed as a global public health priority. For women who are already obese, renewed efforts should be made towards improved management during pregnancy, especially of blood glucose, and increased attention to post-partum weight management. Effective interventions, tailored to ethnicity and culture, are needed at each of these stages to improve the health of women and their children in the context of the global obesity epidemic.
全球范围内,育龄妇女的肥胖患病率呈上升趋势。肥胖会降低生育能力,增加受孕所需时间,而肥胖相关的合并症(如 2 型糖尿病和慢性高血压)会增加孕妇及其子女不良结局的风险。肥胖孕妇更有可能发生早期妊娠丢失,并且胎儿先天畸形、巨大儿分娩、肩难产、自发性和医学指征早产以及死产的风险增加。晚期妊娠并发症包括妊娠期糖尿病和子痫前期,两者均与产后长期发病相关。肥胖妇女在分娩过程中也可能会遇到困难,并且更容易发生产后出血。产后体重滞留以及下一次妊娠的固有并发症与长期健康风险相关。下一代的健康也受到影响。通过预防育龄妇女肥胖,可以避免所有这些健康问题,这应被视为全球公共卫生的重点。对于已经肥胖的妇女,应在妊娠期间加强管理,特别是血糖管理,并更加关注产后体重管理。在这些阶段都需要根据种族和文化制定有效的干预措施,以在全球肥胖流行的背景下改善妇女及其儿童的健康。