Achamrah Najate, Déchelotte Pierre, Coëffier Moïse
aNormandie Univ bINSERM UMR 1073 'Nutrition, Inflammation and Dysfunction of Gut-brain Axis', University of Rouen cNutrition Department, Rouen University Hospital, Rouen, France.
Curr Opin Clin Nutr Metab Care. 2017 Jan;20(1):86-91. doi: 10.1097/MCO.0000000000000339.
Glutamine is the most abundant amino acid in plasma and plays a key role in maintaining the integrity of intestinal barrier.
Experimental studies showed that glutamine is able to modulate intestinal permeability and tight junction protein expression in several conditions. Recent articles underlined its putative beneficial role in gastrointestinal disorders such as irritable bowel syndrome.
Glutamine is a major nutrient to maintain intestinal barrier function in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported. Despite promising data in experimental models, further studies are needed to evaluate glutamine supplementation in clinical practice.
谷氨酰胺是血浆中最丰富的氨基酸，在维持肠道屏障完整性方面发挥关键作用。
实验研究表明，在多种情况下谷氨酰胺能够调节肠道通透性和紧密连接蛋白表达。近期文章强调了其在诸如肠易激综合征等胃肠道疾病中可能的有益作用。
谷氨酰胺是维持动物和人类肠道屏障功能的主要营养素。谷氨酰胺缺乏会导致绒毛萎缩、紧密连接蛋白表达降低以及肠道通透性增加。此外，在多种损伤实验条件和一些临床情况下，补充谷氨酰胺可改善肠道屏障功能。此外，最近报道了谷氨酰胺在肠道损伤实验模型中的预防作用。尽管在实验模型中有令人鼓舞的数据，但仍需要进一步研究以评估临床实践中补充谷氨酰胺的情况。
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