1-甲基-2-[(4-氨基苯基)-磺酰基-]氨基-5-硝基咪唑的合成及生物学性质
Synthesis and biological properties of 1-methyl-2-[(4-aminophenyl)-sulfonyl-]amino-5-nitro imidazole.
作者信息
Bertolini A, Castelli M, Borella F, Dall' Asta L, Comini A, Alberti D, Coppi G
出版信息
Boll Chim Farm. 1989 Feb;128(2):71-3.
PMID:2775520
Abstract
The synthesis of 1-methyl-2-[(4-aminophenyl)sulfonyl] amino-5-nitroimidazole 5 is described. The new sulfonamide 5 shows a good activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria. Compound 5 is well absorbed in rats after oral administration but the plasma levels are inferior to those of sulfadiazine and sulfamethoxazole.
摘要
描述了1-甲基-2-[(4-氨基苯基)磺酰基]氨基-5-硝基咪唑5的合成。新型磺酰胺5对需氧和厌氧革兰氏阳性及革兰氏阴性细菌显示出良好的活性。化合物5经口服给药后在大鼠体内吸收良好，但血浆水平低于磺胺嘧啶和磺胺甲恶唑。
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