苯妥英钠所致儿童脑病
Phenytoin-induced encephalopathy in a child.
作者信息
Mehndiratta Sumit
机构信息
Department of Pediatrics, SDN Hospital, New Delhi, India.
出版信息
Indian J Pharmacol. 2016 Jul-Aug;48(4):460-461. doi: 10.4103/0253-7613.186209.
Abstract
Phenytoin is a commonly used antiepileptic medication in the pediatric age group, but it has a narrow therapeutic range. Various adverse effects have been reported commonly. We report a relatively rare case of encephalopathy in a child from overdose of injectable phenytoin due to ignorance of the previous treatment. Scrutiny of medical records and history is of utmost importance while administering such medications.
摘要
苯妥英钠是儿科常用的抗癫痫药物，但治疗窗较窄。常见多种不良反应的报道。我们报告了一例相对罕见的病例，一名儿童因忽视既往治疗而过量注射苯妥英钠导致脑病。在使用此类药物时，仔细审查病历和病史至关重要。
相似文献
1
Phenytoin-induced encephalopathy in a child.
Indian J Pharmacol. 2016 Jul-Aug;48(4):460-461. doi: 10.4103/0253-7613.186209.
2
Purple glove syndrome caused by oral administration of phenytoin.
J Child Neurol. 2000 Nov;15(11):762. doi: 10.1177/088307380001501110.
3
Severe cardiomyopathy in an infant after iatrogenic fosphenytoin overdose.
Clin Pediatr (Phila). 2014 Jul;53(8):791-3. doi: 10.1177/0009922813505698. Epub 2013 Oct 21.
4
Phenytoin Toxicity.
JAMA. 2017 Jun 20;317(23):2445-2446. doi: 10.1001/jama.2017.6881.
5
EMPACT syndrome.
Cutan Ocul Toxicol. 2011 Dec;30(4):328-30. doi: 10.3109/15569527.2011.588298. Epub 2011 Jun 16.
6
Unusual presentation of iatrogenic phenytoin toxicity in a newborn.
J Med Toxicol. 2005 Dec;1(1):26-9. doi: 10.1007/BF03160902.
7
Case Study Interpretation--Houston: Case 1. Phenytoin-induced ‘‘pseudolymphoma’’.
Cytometry B Clin Cytom. 2011 Jul-Aug;80(4):255-7. doi: 10.1002/cyto.b.20597. Epub 2011 Jun 2.
8
[Decrease of folic acid and cognitive alterations in patients with epilepsy treated with phenytoin or carbamazepine, pilot study].
Rev Invest Clin. 2005 Jul-Aug;57(4):522-31.
9
Phenytoin toxicity with mandibular tremor secondary to intravenous administration.
Int J Clin Pharmacol Ther. 2002 Jan;40(1):18-9. doi: 10.5414/cpp40018.
10
Life-threatening cardiotoxicity due to chronic oral phenytoin overdose.
Neurol India. 2009 Mar-Apr;57(2):200-2. doi: 10.4103/0028-3886.51296.
本文引用的文献
1
Pediatric dosing errors due to variable drug formulations.
J Pharmacol Pharmacother. 2014 Oct;5(4):254-5. doi: 10.4103/0976-500X.142444.
2
Phenytoin toxicity presenting as acute meningo-encephalitis in children.
Neurol India. 2011 Jan-Feb;59(1):66-7. doi: 10.4103/0028-3886.76862.
3
Life-threatening cardiotoxicity due to chronic oral phenytoin overdose.
Neurol India. 2009 Mar-Apr;57(2):200-2. doi: 10.4103/0028-3886.51296.
4
Unusual presentation of iatrogenic phenytoin toxicity in a newborn.
J Med Toxicol. 2005 Dec;1(1):26-9. doi: 10.1007/BF03160902.
5
Acute phenytoin intoxication: causes, symptoms, misdiagnoses, and outcomes.
Kaohsiung J Med Sci. 2004 Dec;20(12):580-5. doi: 10.1016/S1607-551X(09)70262-1.
Zotero 插件