Suppr超能文献

在康复能力有限的情况下对药物滥用流行情况进行建模。

Modelling Drug Abuse Epidemics in the Presence of Limited Rehabilitation Capacity.

作者信息

Mushanyu J, Nyabadza F, Muchatibaya G, Stewart A G R

机构信息

Department of Mathematics, University of Zimbabwe, Box MP 167, Mount Pleasant, Harare, Zimbabwe.

Department of Mathematical Sciences, Stellenbosch University, P. Bag X1, Matieland, 7602, South Africa.

出版信息

Bull Math Biol. 2016 Dec;78(12):2364-2389. doi: 10.1007/s11538-016-0218-5. Epub 2016 Oct 20.

Abstract

The abuse of drugs is now an epidemic globally whose control has been mainly through rehabilitation. The demand for drug abuse rehabilitation has not been matched with the available capacity resulting in limited placement of addicts into rehabilitation. In this paper, we model limited rehabilitation through the Hill function incorporated into a system of nonlinear ordinary differential equations. Not every member of the community is equally likely to embark on drug use, risk structure is included to help differentiate those more likely (high risk) to abuse drugs and those less likely (low risk) to abuse drugs. It is shown that the model has multiple equilibria, and using the centre manifold theory, the model exhibits the phenomenon of backward bifurcation whose implications to rehabilitation are discussed. Sensitivity analysis and numerical simulations are performed. The results show that saturation in rehabilitation will in the long run lead to the escalation of drug abuse. This means that limited access to rehabilitation has negative implications in the fight against drug abuse where rehabilitation is the main form of control. This suggests that increased access to rehabilitation is likely to lower the drug abuse epidemic.

摘要

药物滥用如今在全球范围内泛滥成灾,其管控主要通过康复治疗来进行。对药物滥用康复治疗的需求与现有的治疗能力不匹配,导致成瘾者进入康复治疗机构的安置机会有限。在本文中,我们通过纳入非线性常微分方程组的希尔函数对有限的康复治疗进行建模。并非社区中的每个成员吸毒的可能性都相同,我们纳入了风险结构,以帮助区分那些更有可能(高风险)滥用药物的人和那些不太可能(低风险)滥用药物的人。结果表明,该模型具有多个平衡点,并且运用中心流形理论,该模型呈现出向后分岔现象,并对其对康复治疗的影响进行了讨论。我们进行了敏感性分析和数值模拟。结果表明,从长远来看,康复治疗的饱和将导致药物滥用情况的升级。这意味着在以康复治疗作为主要管控形式的药物滥用防治斗争中,康复治疗机会有限会产生负面影响。这表明增加康复治疗机会可能会降低药物滥用的泛滥程度。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验