用激进的剪刀切断胆碱。
Cutting Choline with Radical Scissors.
机构信息
Department of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Department of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.
出版信息
Cell Chem Biol. 2016 Oct 20;23(10):1173-1174. doi: 10.1016/j.chembiol.2016.10.002.
The human gut microbiome is the source of not only microbial diversity, but also of interesting chemical reactions and enzymology. An excellent example of this is CutC, an enzyme that makes trimethylamine (TMA). In this issue of Cell Chemical Biology, Bodea et al. (2016) show how CutC uses a glycyl radical to perform C-N bond cleavage needed for TMA production.
人类肠道微生物群不仅是微生物多样性的来源，也是有趣的化学反应和酶学的来源。CutC 就是一个很好的例子，它是一种能够产生三甲胺（TMA）的酶。在本期《细胞化学生物学》中，Bodea 等人（2016）展示了 CutC 如何利用甘氨酰基自由基来进行 C-N 键的断裂，从而产生 TMA。
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