茴香脑及其在慢性疾病中的作用。

Anethole and Its Role in Chronic Diseases.

作者信息

Aprotosoaie Ana Clara, Costache Irina-Iuliana, Miron Anca

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.

Department of Internal Medicine, Faculty of Medicine, "Sf. Spiridon" University Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.

出版信息

Adv Exp Med Biol. 2016;929:247-267. doi: 10.1007/978-3-319-41342-6_11.

DOI:10.1007/978-3-319-41342-6_11

PMID:27771928

Abstract

Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anticarcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-α signaling, and various ion channels. This chapter aims to review the scientific data and attempts to provide an insight into pharmacological activity of anethole and its therapeutic potential in human chronic diseases.

摘要

茴香脑是茴芹、茴香和八角香料以及其他20多种植物物种中的主要香气成分和生物活性化合物。它在食品工业和其他行业、化妆品、香水和制药领域中被广泛用作调味剂。在过去几年中，各种研究揭示了茴香脑对人类健康的多种有益作用，如抗炎、抗癌和化学预防、抗糖尿病、免疫调节、神经保护或抗血栓形成作用，这些作用是通过调节几种细胞信号通路介导的，主要是NF-κB和TNF-α信号通路以及各种离子通道。本章旨在综述科学数据，并试图深入了解茴香脑的药理活性及其在人类慢性疾病中的治疗潜力。