来自日本慢性和亚急性猪丹毒的豕红斑丹毒丝菌Met-203型SpaA菌株的致病性特征
Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan.
作者信息
Uchiyama Mariko, Shimazaki Yohko, Isshiki Yukari, Kojima Akemi, Hirano Fumiya, Yamamoto Kinya, Kijima Mayumi, Nagai Hidetaka
机构信息
National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
出版信息
J Vet Med Sci. 2017 Jan 20;79(1):18-21. doi: 10.1292/jvms.16-0164. Epub 2016 Oct 21.
Abstract
To characterize the Erysipelothrix rhusiopathiae Met-203 type surface protective antigen (Spa) A strains causing swine erysipelas in Japan, the nucleotide sequence of the hypervariable region of the spaA gene was determined in 80 E. rhusiopathiae (serotype 1a) isolates collected from pigs with chronic and subacute swine erysipelas in 14 prefectures in 2008-2014. In this study, 14 (17.5%) isolates were Met-203 type SpaA strains. We confirmed the pathogenicity of a Met-203 type SpaA strain in specific-pathogen-free pigs. In this experiment, the two challenged pigs displayed arthritis, urticaria and other clinical signs, but recovered within 10 days. Our results reveal the existence of the E. rhusiopathiae Met-203 type strains that have been causing chronic erysipelas in Japan.
摘要
为了鉴定在日本引起猪丹毒的猪红斑丹毒丝菌Met-203型表面保护性抗原（Spa）A菌株，测定了2008年至2014年从14个县患有慢性和亚急性猪丹毒的猪中分离出的80株猪红斑丹毒丝菌（血清型1a）spaA基因高变区的核苷酸序列。在本研究中，14株（17.5%）分离株为Met-203型SpaA菌株。我们证实了一株Met-203型SpaA菌株对无特定病原体猪的致病性。在该实验中，两只受试猪出现关节炎、荨麻疹和其他临床症状，但在10天内康复。我们的结果揭示了在日本一直引起慢性丹毒的猪红斑丹毒丝菌Met-203型菌株的存在。
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