Dailloux M, Petitpain N, Henry C, Weber M
Laboratoire de Microbiologie, Centre Hospitalier Régional Universitaire, Nancy-Brabois, Vandoeuvre.
Pathol Biol (Paris). 1989 May;37(5):346-9.
In vitro activity of four fluorinated quinolones: pefloxacin, norfloxacin, ciprofloxacin, ofloxacin were determined against various clinical isolates of mycobacteria. The method of agar dilution was used, seventy strains of ten species were tested: Mycobacterium tuberculosis (25), Mycobacterium bovis (5), Mycobacterium africanum (2), BCG (5), Mycobacterium kansasii (6), Mycobacterium marinum (5), Mycobacterium avium (11), Mycobacterium xenopi (6), Mycobacterium chelonae (3), Mycobacterium fortuitum (2). Except for Mycobacterium avium and Mycobacterium chelonae (CMI 100% greater than 8 mg/l) fluorinated quinolones showed activity against tested mycobacteria (CMI 100% less than or equal to 8 mg/l). Ofloxacin and ciprofloxacin where found to be the most active. Their activity against the different strains of Mycobacterium tuberculosis was unrelated to their susceptibility or resistance to the antituberculous drugs.
培氟沙星、诺氟沙星、环丙沙星、氧氟沙星对各种临床分离分枝杆菌的体外活性。采用琼脂稀释法，检测了十个菌种的70株菌：结核分枝杆菌（25株）、牛分枝杆菌（5株）、非洲分枝杆菌（2株）、卡介苗（5株）、堪萨斯分枝杆菌（6株）、海分枝杆菌（5株）、鸟分枝杆菌（11株）、偶发分枝杆菌（6株）、龟分枝杆菌（3株）、脓肿分枝杆菌（2株）。除鸟分枝杆菌和龟分枝杆菌（最低抑菌浓度100%大于8mg/l）外，氟喹诺酮类药物对受试分枝杆菌有活性（最低抑菌浓度100%小于或等于8mg/l）。发现氧氟沙星和环丙沙星活性最强。它们对不同结核分枝杆菌菌株的活性与其对抗结核药物的敏感性或耐药性无关。
