[外周血自然杀伤细胞表面CD NKG2D及血清sMICA在鼻型结外NK/T细胞淋巴瘤患者中的意义]
[The significance of peripheral blood natural killer cell surface CD NKG2D and serum sMICA in patients with extranodal NK/T cell lymphoma, nasal type].
作者信息
Liu J X, Wang J W, Cui X Y
机构信息
Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
出版信息
Zhonghua Nei Ke Za Zhi. 2016 Nov 1;55(11):872-874. doi: 10.3760/cma.j.issn.0578-1426.2016.11.012.
The expression of CD NKG2D on the surface of natural killer (NK) cells and serum soluble major histocompatibility complex class Ⅰ chain-related A (sMICA) level in patients with extranodal NK/T cell lymphoma, nasal type (ENKL) were detected.We found that CD expression was reduced on the surface of NK cells, suggesting impaired NK cell activity in ENKL patients, which may result from decreased NKG2D expression.
检测鼻型结外NK/T细胞淋巴瘤（ENKL）患者自然杀伤（NK）细胞表面CD NKG2D的表达及血清可溶性主要组织相容性复合体Ⅰ类链相关分子A（sMICA）水平。我们发现NK细胞表面CD表达降低，提示ENKL患者NK细胞活性受损，这可能是由于NKG2D表达降低所致。
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