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一名无症状患者双侧卵巢和子宫的血管内大B细胞淋巴瘤伴t(11;22)(q23;q11) 染色体易位。

Intravascular Large B-cell Lymphoma of the Bilateral Ovaries and Uterus in an Asymptomatic Patient with a t(11;22)(q23;q11) Constitutional Translocation.

作者信息

Shigematsu Yasuyuki, Matsuura Motoki, Nishimura Noriko, Tsuyama Naoko, Takeuchi Kengo, Terui Yasuhito, Takeshima Nobuhiro, Hatake Kiyohiko

机构信息

Division of Hematology Oncology, The Cancer Institute Hospital, Japanese Foundation of Cancer Research, Japan.

出版信息

Intern Med. 2016;55(21):3169-3174. doi: 10.2169/internalmedicine.55.6578. Epub 2016 Nov 1.

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma, which is characterized by the intravascular growth of lymphoma cells, aggressive behavior, and an often fatal course. Patients with IVLBCL are usually symptomatic. Although any organ may be involved, localized lesions in the bilateral ovaries and uterus are extremely rare. We experienced a rare case of IVLBCL involving the bilateral ovaries and uterus in an asymptomatic patient with a t(11;22)(q23;q11) constitutional balanced translocation. Its association with the disease remains unknown. Even in asymptomatic situations, IVLBCL is possible, and the uterus and ovaries can be involved.

摘要

血管内大B细胞淋巴瘤(IVLBCL)是结外弥漫性大B细胞淋巴瘤的一种罕见亚型,其特征为淋巴瘤细胞在血管内生长、侵袭性生物学行为及通常致命的病程。IVLBCL患者通常有症状。尽管任何器官均可受累,但双侧卵巢和子宫的局限性病变极为罕见。我们遇到1例罕见的IVLBCL病例,该无症状患者存在t(11;22)(q23;q11) 染色体平衡易位,双侧卵巢和子宫均受累。其与该疾病的关联尚不清楚。即使在无症状情况下,IVLBCL也有可能发生,子宫和卵巢也可受累。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee35/5140869/7b36415b5b9d/1349-7235-55-3169-g001.jpg

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