Wang Huajun, Cheng Yanmei, Shao Decheng, Chen Junyuan, Sang Yuan, Gui Tao, Luo Simin, Li Jieruo, Chen Chao, Ye Yongguang, Yang Yong, Li Yikai, Zha Zhengang
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Evid Based Complement Alternat Med. 2016;2016:7242478. doi: 10.1155/2016/7242478. Epub 2016 Oct 11.
. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. . Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. . The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38-3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03-1.07, < 0.00001). No publication bias was found in the present meta-analysis. . The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.
研究表明，代谢因素可能在骨关节炎（OA）发病机制中起重要作用。人们对了解膝骨关节炎与代谢综合征（MetS）之间的关系越来越感兴趣。本研究的目的是通过荟萃分析探讨代谢综合征与膝骨关节炎之间的关联。检索了包括PUBMED、EMBASE和Cochrane图书馆在内的数据库以获取相关研究。由两位作者分别提取数据，并计算合并优势比（OR）及95%置信区间（CI）。最终从数据库检索中纳入8项研究，共3202例病例和20968例对照，完成了荟萃分析。粗合并OR为2.24（95%CI = 1.38 - 3.64）。尽管这些研究之间存在显著异质性，且主要由一项研究导致，但排除该研究后风险增加仍具有显著性。合并调整后的OR仍然显著，合并调整后的OR为1.05（95%CI = 1.03 - 1.07，P < 0.00001）。本荟萃分析未发现发表偏倚。现有证据的综合分析支持，即使在调整了许多风险因素后，代谢综合征仍会增加膝骨关节炎的风险。
