宫颈发育不良患者中 VEGF +936 C/T 基因多态性。
VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia.
机构信息
1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy "Iuliu Hatieganu", Clinicilor 3-5, 400006 Cluj-Napoca, Romania.
Department of Economic Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania.
出版信息
Anal Cell Pathol (Amst). 2016;2016:6074275. doi: 10.1155/2016/6074275. Epub 2016 Oct 12.
. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. . One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05. . No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], = 0.0866. . No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.
. 本研究旨在分析 VEGF +936 C/T 多态性在子宫颈上皮内瘤变中的潜在作用。. 研究共纳入 186 例患者：75 例（诊断为 CIN 的患者）和 111 例对照（HPV 检测和细胞学均为阴性）。每位患者在进行阴道镜检查时安排单次就诊。从宫颈标本中进行细胞学和 HPV 检测，并从外周血中确定 VEGF +936 基因分型。为了进行统计分析，采用 OR 和卡方检验，显著性水平为 <0.05。. 在病例与对照组中未发现 CT 基因型的检出存在关联，OR = 0.8295，[0.42，1.62]。T 等位基因与 HSIL 呈负相关，OR = 0.2121，[0.0473，0.9517]，= 0.0866。. 在 VEGF +936 C/T 与子宫颈上皮内瘤变之间未发现关联。
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