与痴呆症相关的载脂蛋白E ε4等位基因与快速眼动睡眠行为障碍无关。

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.

作者信息

Gan-Or Ziv, Montplaisir Jacques Y, Ross Jay P, Poirier Judes, Warby Simon C, Arnulf Isabelle, Strong Stephanie, Dauvilliers Yves, Leblond Claire S, Hu Michele T M, Högl Birgit, Stefani Ambra, Monaca Christelle Charley, De Cock Valérie Cochen, Boivin Michel, Ferini-Strambi Luigi, Plazzi Giuseppe, Antelmi Elena, Young Peter, Heidbreder Anna, Barber Thomas R, Evetts Samuel G, Rolinski Michal, Dion Patrick A, Desautels Alex, Gagnon Jean-François, Dupré Nicolas, Postuma Ronald B, Rouleau Guy A

机构信息

Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.

Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.

出版信息

Neurobiol Aging. 2017 Jan;49:218.e13-218.e15. doi: 10.1016/j.neurobiolaging.2016.10.002. Epub 2016 Oct 13.

DOI:10.1016/j.neurobiolaging.2016.10.002

PMID:27814994

Abstract

The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

摘要

本研究旨在探讨与路易体痴呆（DLB）相关且可能与帕金森病（PD）痴呆相关的载脂蛋白E（APOE）ε4等位基因是否也与特发性快速眼动睡眠行为障碍（RBD）相关。对480例RBD患者和823例对照者进行了两个单核苷酸多态性rs429358和rs7412的基因分型。RBD患者中APOE ε4等位基因频率为0.14，对照者中为0.13（比值比[OR]=1.11，95%置信区间[CI]：0.88 - 1.40，p=0.41）。转化为DLB者（0.14）、转化为帕金森病者（0.12）或多系统萎缩者（0.14，p=1.0）的APOE ε4等位基因频率相似。APOE ε4等位基因既不是RBD的危险因素，也与RBD转化为DLB或其他突触核蛋白病无关。