一种饲料中添加伊维菌素的制剂对猪胃肠道蠕虫、肺线虫和疥螨的疗效。

Efficacy of an in-feed ivermectin formulation against gastrointestinal helminths, lungworms, and sarcoptic mites in swine.

作者信息

Alva-Valdes R, Wallace D H, Foster A G, Ericsson G F, Wooden J W

机构信息

Animal Science Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

出版信息

Am J Vet Res. 1989 Aug;50(8):1392-5.

PMID:2782722

Abstract

The efficacy of ivermectin as an in-feed formulation was evaluated against naturally acquired gastrointestinal helminths, lungworms, and sarcoptic mites (experiment 1; n = 24) and against induced infection with intestinal nematodes (experiment 2; n = 24) in pigs. Treatments consisted of ivermectin administered in feed at concentrations calculated to provide 100 or 200 micrograms/kg of body weight/d for 7 days or of nonmedicated feed (controls) for 7 days. At concentration of 100 micrograms of ivermectin/kg/d, efficacy against naturally acquired infections was 97.7% for Ascaris suum, 97.8% for Metastrongylus spp, greater than 99% for Oesophagostomum spp, 100% for Macracanthorhynchus hirudinaceus, and 89.7% for Ascarops strongylina. Against induced infections (fourth-stage larvae), efficacy was 100% for A suum and 96.9% for Oesophagostomum spp. At concentration of 200 micrograms of ivermectin/kg/d, efficacy against naturally acquired infections was 100% for A suum, Hyostrongylus rubidus, Metastrongylus spp, and Ascarops strongylina; greater than 99% for Oesophagostomum spp; and 85.9% for Macracanthorhynchus hirudinaceus. Against induced infections (fourth-stage larvae), efficacy was 100% for A suum and 95% for Oesophagostomum spp. At concentrations of 100 and 200 micrograms of ivermectin/kg/d, efficacy against Sarcoptes scabiei var suis was evidenced by elimination of the mite by posttreatment day 14.

摘要

在猪身上评估了伊维菌素作为饲料添加剂对自然感染的胃肠道蠕虫、肺线虫和疥螨（实验1；n = 24）以及对肠道线虫人工感染（实验2；n = 24）的疗效。治疗方法包括以计算出的浓度在饲料中添加伊维菌素，以提供100或200微克/千克体重/天的剂量，持续7天，或给予7天的无药饲料（对照组）。在伊维菌素浓度为100微克/千克/天的情况下，对自然感染的疗效为：猪蛔虫97.7%，后圆线虫属97.8%，食道口线虫属大于99%，蛭形巨吻棘头虫100%，猪蛔状线虫89.7%。对人工感染（第四期幼虫），猪蛔虫的疗效为100%，食道口线虫属为96.9%。在伊维菌素浓度为200微克/千克/天的情况下，对自然感染的疗效为：猪蛔虫、红色猪圆线虫、后圆线虫属和猪蛔状线虫均为100%；食道口线虫属大于99%；蛭形巨吻棘头虫为85.9%。对人工感染（第四期幼虫），猪蛔虫的疗效为100%，食道口线虫属为95%。在伊维菌素浓度为100和200微克/千克/天的情况下，在治疗后第14天螨虫消失证明了对猪疥螨的疗效。