溃疡性结肠炎患者发育异常息肉的低患病率。

Low prevalence of dysplastic polyps in patients with ulcerative colitis.

作者信息

Laish Ido, Shurani Amir, Barkay Olga, Konikoff Fred Meir, Naftali Timna

机构信息

Gastroenterology and Hepatology Institute, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Gastroenterology and Hepatology Institute, Meir Medical Center, Kfar Saba, Israel.

出版信息

Clin Res Hepatol Gastroenterol. 2017 Mar;41(2):204-209. doi: 10.1016/j.clinre.2016.09.009. Epub 2016 Nov 9.

DOI:10.1016/j.clinre.2016.09.009

PMID:27838112

Abstract

BACKGROUND AND AIMS

Patients with ulcerative colitis (UC) are prone to colorectal cancer and dysplastic polyps and also have sporadic adenomas. There is scant information, however, relating the prevalence of sporadic adenomas in UC patients compared with normal subjects. The aim of this study was to assess the prevalence of all dysplastic lesions in UC and compare the prevalence of adenomas to that in the general population.

METHODS

A single-center retrospective study, in which all patients with diagnosed UC were followed during a ten-year period. The incidence of polyps and colorectal cancers were recorded and compared to that of an age-matched group in the general population who had screening colonoscopy.

RESULTS

A total of 229 UC patients were included compared with 450 age-matched subjects who underwent a single colonoscopy. The average number of colonoscopies per UC patient was 3. The rate of sporadic adenomas among UC patients (9.6%), as well as the rate of all dysplastic polyps (11.2%) in these patients, were significantly lower than the rate of adenomas among the control population (24%; OR 0.33-0.44; P<0.0001). Despite this, the rates of colon cancer were comparable between the groups (2.1% vs. 1.5%, P=0.55).

CONCLUSIONS

In spite of the observed lower rate of dysplastic polyps in UC patients, this should not preclude tight surveillance in this high-risk population.

摘要

背景与目的

溃疡性结肠炎（UC）患者易患结直肠癌和发育异常息肉，也会出现散发性腺瘤。然而，与正常受试者相比，关于UC患者散发性腺瘤患病率的信息却很少。本研究的目的是评估UC患者中所有发育异常病变的患病率，并将腺瘤的患病率与普通人群进行比较。

方法

一项单中心回顾性研究，对所有确诊为UC的患者进行了为期十年的随访。记录息肉和结直肠癌的发病率，并与接受结肠镜筛查的普通人群中年龄匹配组的发病率进行比较。

结果

共纳入229例UC患者，与之相比，450例年龄匹配的受试者接受了单次结肠镜检查。每位UC患者的平均结肠镜检查次数为3次。UC患者中散发性腺瘤的发生率（9.6%）以及这些患者中所有发育异常息肉的发生率（11.2%）均显著低于对照组人群中腺瘤的发生率（24%；比值比0.33 - 0.44；P<0.0001）。尽管如此，两组之间的结肠癌发生率相当（2.1%对1.5%，P = 0.55）。