锌水平与自闭症之间的关系：一项系统评价与荟萃分析。
The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis.
作者信息
Babaknejad Nasim, Sayehmiri Fatemeh, Sayehmiri Kourosh, Mohamadkhani Ashraf, Bahrami Somaye
机构信息
Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Department of Social Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.; Department of Biostatistics, Research Center for Prevention of psychosocial impairment, University of Ilam, Ilam, Iran.
出版信息
Iran J Child Neurol. 2016 Fall;10(4):1-9.
OBJECTIVE
Autism is a complex behaviorally defined disorder.There is a relationship between zinc (Zn) levels in autistic patients and development of pathogenesis, but the conclusion is not permanent.
MATERIALS & METHODS: The present study conducted to estimate this probability using meta-analysis method. In this study, Fixed Effect Model, twelve articles published from 1978 to 2012 were selected by searching Google scholar, PubMed, ISI Web of Science, and Scopus and information were analyzed. I² statistics were calculated to examine heterogeneity. The information was analyzed using R and STATA Ver. 12.2.
RESULTS
There was no significant statistical difference between hair, nail, and teeth Zn levels between controls and autistic patients: -0.471 [95% confidence interval (95% CI): -1.172 to 0.231]. There was significant statistical difference between plasma Zn concentration and autistic patients besides healthy controls: -0.253 (95% CI: 0.498 to -0.007). Using a Random Effect Model, the overall Integration of data from the two groups was -0.414 (95% CI: -0.878 to -0.051).
CONCLUSION
Based on sensitivity analysis, zinc supplements can be used for the nutritional therapy for autistic patients.
目的
自闭症是一种复杂的行为定义障碍。自闭症患者体内锌（Zn）水平与发病机制的发展之间存在关联，但结论并不一致。
材料与方法
本研究采用荟萃分析方法来评估这种可能性。在本研究中，通过检索谷歌学术、PubMed、ISI科学网和Scopus，选取了1978年至2012年发表的12篇文章，并对信息进行分析。计算I²统计量以检验异质性。使用R和STATA 12.2版本对信息进行分析。
结果
对照组与自闭症患者的头发、指甲和牙齿中的锌水平之间无显著统计学差异：-0.471[95%置信区间（95%CI）：-1.172至0.231]。除健康对照组外，血浆锌浓度与自闭症患者之间存在显著统计学差异：-0.253（95%CI：0.498至-0.007）。使用随机效应模型，两组数据的总体合并结果为-0.414（95%CI：-0.878至-0.051）。
结论
基于敏感性分析，锌补充剂可用于自闭症患者的营养治疗。
Zotero 插件