对乙酰氨基酚与硫酸镁在手术期间镇痛效果的比较。
Comparison of the Analgesic Effect of Paracetamol and Magnesium Sulfate during Surgeries.
作者信息
Kalani Navid, Sanie Mohammad Sadegh, Zabetian Hasan, Radmehr Mohammad, Sahraei Reza, Kargar Jahromi Hossein, Zare Marzouni Hadi
机构信息
Medical Ethic Research Center, Jahrom University of Medical Sciences, Jahrom, Iran;; Department of Anaesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran.
Department of Anaesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran;; Research Center For Social Determinants Of Health, Jahrom University of Medical Sciences, Jahrom, Iran.
出版信息
World J Plast Surg. 2016 Sep;5(3):280-286.
BACKGROUND
New drugs are increasingly used to induce analgesia during surgeries. This study compared the analgesic effects of paracetamol and magnesium sulfate.
METHODS
Sixty patients with American Society of Anesthesiologists (ASA) class I or II patients who were candidates for surgery of the lower limbs were randomly divided into three equal groups who were age and gender matched. Group 1 received paracetamol, and group 2, the magnesium sulfate during surgery and group 3 as the control. Pain intensities were measured and recorded using the Visual Analog Scale before surgery, in the recovery room, and 6, 12, and 18 hours after surgery.
RESULTS
Pain intensities (7.10, 5.80, and 4.10) were higher in the control group; 6, 12, and 18 hours after surgery compared to the paracetamol (6.45, 4.15, 2.50) and the magnesium groups (7.25, 4.55, and 2.05), but the difference was not statistically significant.
CONCLUSION
Paracetamol and magnesium sulfate were shown to have postoperative analgesic effects and reduce the quantity of narcotic use after surgery.
背景
在手术过程中，越来越多地使用新药来诱导镇痛。本研究比较了对乙酰氨基酚和硫酸镁的镇痛效果。
方法
将60例美国麻醉医师协会（ASA）I或II级、拟行下肢手术的患者随机分为三组，三组年龄和性别相匹配，每组人数相等。第1组在手术期间接受对乙酰氨基酚，第2组接受硫酸镁，第3组作为对照组。在手术前、恢复室以及手术后6、12和18小时，使用视觉模拟量表测量并记录疼痛强度。
结果
与对乙酰氨基酚组（6.45、4.15、2.50）和硫酸镁组（7.25、4.55、2.05）相比，对照组在术后6、12和18小时的疼痛强度（7.10、5.80、4.10）更高，但差异无统计学意义。
结论
对乙酰氨基酚和硫酸镁均具有术后镇痛作用，并可减少术后麻醉药物的使用量。
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