建模、信号传导与细胞骨架动力学：细胞迁移中的综合建模-实验框架
Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration.
作者信息
Sun Meng, Zaman Muhammad H
机构信息
Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Howard Hughes Medical Institute, Boston, MA, USA.
出版信息
Wiley Interdiscip Rev Syst Biol Med. 2017 Jan;9(1). doi: 10.1002/wsbm.1365. Epub 2016 Nov 15.
Cell migration is a complex and multistep process involved in homeostasis maintenance, morphogenesis, and disease development, such as cancer metastasis. Modeling cell migration and the relevant cytoskeleton dynamics have profound implications for studying fundamental development and disease diagnosis. This review focuses on some recent models of both cell migration and migration-related cytoskeleton dynamics, addressing issues such as the difference between amoeboid and mesenchymal migration modes, and between single-cell migration and collective cell migration. The review also highlights the computational integration among variable external cues, especially the biochemical and mechanical signaling that affects cell migration. Finally, we aim to identify the gaps in our current knowledge and potential strategies to develop integrated modeling-experimental frameworks for multiscale behavior integrating gene expression, cell signaling, mechanics, and multicellular dynamics. WIREs Syst Biol Med 2017, 9:e1365. doi: 10.1002/wsbm.1365 For further resources related to this article, please visit the WIREs website.
细胞迁移是一个复杂的多步骤过程，涉及体内平衡维持、形态发生以及疾病发展，如癌症转移。对细胞迁移及相关细胞骨架动力学进行建模，对于研究基础发育和疾病诊断具有深远意义。本综述聚焦于细胞迁移和迁移相关细胞骨架动力学的一些最新模型，探讨诸如阿米巴样迁移模式与间充质迁移模式之间、单细胞迁移与集体细胞迁移之间的差异等问题。该综述还强调了可变外部线索之间的计算整合，尤其是影响细胞迁移的生化和机械信号。最后，我们旨在找出当前知识中的差距以及潜在策略，以开发用于整合基因表达、细胞信号传导、力学和多细胞动力学的多尺度行为的综合建模 - 实验框架。WIREs 系统生物学与医学 2017 年，9:e1365。doi:10.1002/wsbm.1365 有关本文的更多资源，请访问WIREs网站。
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