Shang Yingying, Hao Wenyang, Gao Zhiqiang, Xu Chunxiao, Ru Ying, Ni Daofeng
Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Int J Pediatr Otorhinolaryngol. 2016 Dec;91:141-145. doi: 10.1016/j.ijporl.2016.10.025. Epub 2016 Oct 26.
This study evaluated the efficacy of a sequential hearing screening protocol using transient evoked otoacoustic emission (TEOAE) and automated auditory brainstem response (AABR) tests in healthy newborns.
A TEOAE screening was performed during the first 48-72 h of life. If the infants failed, an AABR test was performed at the same time, and they were referred for a TEOAE rescreening at six weeks old. The results of screening Protocol 1 (only TEOAE) were compared with those of screening Protocol 2 (sequential TEOAE + AABR screenings for the first screening and TEOAE for the rescreening).
A total of 1062 healthy newborns were enrolled in this research.
For Protocol 1, the first screening and rescreening referral rates were 11.1% and 2.2%, respectively. In contrast, for Protocol 2, the referral rates were significant lower at 3.8% and 0.9%, respectively. Using the two protocols, six infants were diagnosed with hearing loss (0.57%).
Adding simultaneous AABR tests for infants who fail TEOAE testing at the first screening stage can significantly reduce referral rates without increasing misdiagnosis rates. Although this sequential screening process involves slightly more time and has a higher cost than TEOAE alone, its greater accuracy compensates for this difference.
本研究评估了在健康新生儿中使用瞬态诱发耳声发射(TEOAE)和自动听性脑干反应(AABR)测试的序贯听力筛查方案的疗效。
在出生后的头48 - 72小时内进行TEOAE筛查。如果婴儿筛查未通过,则同时进行AABR测试,并在六周龄时进行TEOAE复筛。将筛查方案1(仅TEOAE)的结果与筛查方案2(首次筛查采用序贯TEOAE + AABR筛查,复筛采用TEOAE)的结果进行比较。
本研究共纳入1062名健康新生儿。
对于方案1,首次筛查和复筛转诊率分别为11.1%和2.2%。相比之下,对于方案2,转诊率显著更低,分别为3.8%和0.9%。使用这两种方案,6名婴儿被诊断为听力损失(0.57%)。
在首次筛查阶段对TEOAE测试未通过的婴儿同时增加AABR测试可显著降低转诊率,且不增加误诊率。尽管这种序贯筛查过程比单独使用TEOAE稍微耗时更多且成本更高,但其更高的准确性弥补了这一差异。