Tziomalos Konstantinos, Gkougkourelas Ioannis, Sarantopoulos Alexandros, Bekiari Eleni, Makri Evangelia, Raptis Nikolaos, Tselios Konstantinos, Pantoura Marianna, Hatzitolios Apostolos I, Boura Panagiota
First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 54636, Thessaloníki, Greece.
Clinical Immunology Unit, Second Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloníki, Greece.
Rheumatol Int. 2017 Feb;37(2):293-298. doi: 10.1007/s00296-016-3610-4. Epub 2016 Nov 21.
Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. We aimed to evaluate arterial stiffness and the ankle brachial index (ABI), two markers of subclinical cardiovascular disease, in SLE. We studied 55 patients with SLE (12.7% males, age 53.3 ± 15.3 years) and 61 age- and gender-matched controls. Arterial stiffness was evaluated by measuring pulse wave velocity (PWV), augmentation index (AIx) and central systolic, diastolic, pulse and mean blood pressure (BP). Peripheral arterial disease was defined as ABI ≤ 0.90. Regarding markers of arterial stiffness, patients with SLE had lower PWV and AIx than controls (p < 0.01 and p < 0.05, respectively). However, after adjusting for differences in cardiovascular risk factors between patients with SLE and controls, PWV and AIx did not differ between the two groups. Central systolic, diastolic, pulse and mean BP also did not differ between the two groups. In patients with SLE, PWV correlated independently with systolic BP (B = 0.05, p < 0.001) and waist/hip ratio (B = 6.72, p < 0.05). Regarding ABI, the lowest ABI was lower in patients with SLE than in controls (p < 0.005). However, after adjusting for differences in cardiovascular risk factors between patients with SLE and controls, the lowest ABI did not differ between the two groups. The prevalence of PAD also did not differ between patients with SLE and controls (10.0 and 5.4%, respectively; p = NS). Markers of arterial stiffness and the ABI do not appear to differ between patients with SLE and age- and gender-matched controls. However, given the small sample size, larger studies are needed to clarify whether SLE promotes arterial stiffness and PAD.
系统性红斑狼疮（SLE）与心血管风险增加相关。我们旨在评估SLE患者的动脉僵硬度和踝臂指数（ABI）这两个亚临床心血管疾病的标志物。我们研究了55例SLE患者（男性占12.7%，年龄53.3±15.3岁）以及61例年龄和性别匹配的对照者。通过测量脉搏波速度（PWV）、增强指数（AIx）以及中心收缩压、舒张压、脉压和平均血压（BP）来评估动脉僵硬度。外周动脉疾病定义为ABI≤0.90。关于动脉僵硬度的标志物，SLE患者的PWV和AIx低于对照者（分别为p<0.01和p<0.05）。然而，在对SLE患者和对照者之间心血管危险因素的差异进行校正后，两组之间的PWV和AIx并无差异。两组之间的中心收缩压、舒张压、脉压和平均血压也无差异。在SLE患者中，PWV与收缩压（B=0.05，p<0.001）和腰臀比（B=6.72，p<0.05）独立相关。关于ABI，SLE患者的最低ABI低于对照者（p<0.005）。然而，在对SLE患者和对照者之间心血管危险因素的差异进行校正后，两组之间的最低ABI并无差异。SLE患者和对照者之间外周动脉疾病的患病率也无差异（分别为10.0%和5.4%；p=无统计学意义）。SLE患者与年龄和性别匹配的对照者之间，动脉僵硬度标志物和ABI似乎并无差异。然而，鉴于样本量较小，需要开展更大规模的研究来阐明SLE是否会促进动脉僵硬度和外周动脉疾病的发生。
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