乌拉圭一株携带多种耐药基因的去羧勒克菌临床分离株的首次报告及文献综述
First report of a clinical isolate of Leclercia adecarboxylata harbouring multiple resistance genes in Uruguay and review of the literature.
作者信息
García-Fulgueiras Virginia, Seija Verónica, Aguerrebere Paula, Cordeiro Nicolás F, Vignoli Rafael
机构信息
Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Sección Bacteriología, Laboratorio Central, Hospital Pasteur, Administración de los Servicios de Salud del Estado, Larravide S/N, Montevideo, Uruguay.
出版信息
J Glob Antimicrob Resist. 2014 Jun;2(2):77-81. doi: 10.1016/j.jgar.2014.01.002. Epub 2014 Feb 4.
Here we report the detection of a Leclercia adecarboxylata strain, isolated from a case of osteomyelitis, harbouring multiple antibiotic resistance genes encoded on a 450-kb IncHI1/HI2 conjugative plasmid (pLa12). The plasmid carried a complex class 1 integron with the genetic array intI1-aac(6')-Ib-cr-bla-catB3-arr3-qacEΔ1-sul1-ISCR1; in addition, a bla-like allele linked to ampR-qacEΔ1-sul1 as well as bla, bla and qnrB4-like genes were found. To the best of our knowledge, this is the first report of L. adecarboxylata harbouring transferable resistance genes to quinolones, chloramphenicol and rifampicin as well as a plasmidic class C β-lactamase.
在此，我们报告了从一例骨髓炎病例中分离出的一株非脱羧勒克菌，该菌株携带一个450 kb的IncHI1/HI2接合质粒（pLa12）上编码的多个抗生素抗性基因。该质粒携带一个复杂的1类整合子，其基因阵列包括intI1-aac(6')-Ib-cr-bla-catB3-arr3-qacEΔ1-sul1-ISCR1；此外，还发现了一个与ampR-qacEΔ1-sul1连锁的bla样等位基因以及bla、bla和qnrB4样基因。据我们所知，这是关于非脱羧勒克菌携带对喹诺酮类、氯霉素和利福平的可转移抗性基因以及质粒C类β-内酰胺酶的首次报道。
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