纳米颗粒CT造影剂的合成及研究。
Synthesis of nanoparticle CT contrast agents: and studies.
作者信息
Kim Sung June, Xu Wenlong, Ahmad Md Wasi, Baeck Jong Su, Chang Yongmin, Bae Ji Eun, Chae Kwon Seok, Kim Tae Jeong, Park Ji Ae, Lee Gang Ho
机构信息
Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea.
Department of Molecular Medicine and Medical & Biological Engineering, School of Medicine, KNU and Hospital, Taegu 702-701, Korea.
出版信息
Sci Technol Adv Mater. 2015 Oct 9;16(5):055003. doi: 10.1088/1468-6996/16/5/055003. eCollection 2015 Oct.
Water-soluble and biocompatible D-glucuronic acid coated NaWO and BaCO nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ± 0.1 and 2.8 ± 0.1 nm for D-glucuronic acid coated NaWO and BaCO nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated NaWO nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.
首次合成了水溶性且具有生物相容性的D-葡萄糖醛酸包覆的钨酸钠和碳酸钡纳米颗粒，用作X射线计算机断层扫描（CT）造影剂。D-葡萄糖醛酸包覆的钨酸钠和碳酸钡纳米颗粒的平均粒径分别为3.2±0.1纳米和2.8±0.1纳米。所有纳米颗粒均表现出强烈的X射线衰减。静脉注射D-葡萄糖醛酸包覆的钨酸钠纳米颗粒的水性样品悬浮液后获得了CT图像，肾脏中明显出现了阳性对比增强。这些发现表明，本研究报道的纳米颗粒可能是有前景的CT造影剂。
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