衰老的压力
The Pressure of Aging.
作者信息
AlGhatrif Majd, Wang Mingyi, Fedorova Olga V, Bagrov Alexei Y, Lakatta Edward G
机构信息
Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA; Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA.
出版信息
Med Clin North Am. 2017 Jan;101(1):81-101. doi: 10.1016/j.mcna.2016.08.006.
Abstract
Significant hemodynamic changes ensue with aging, leading to an ever-growing epidemic of hypertension. Alterations in central arterial properties play a major role in these hemodynamic changes. These alterations are characterized by an initial decline in aortic distensibility and an increase of diastolic blood pressure, followed by a sharp increase in pulse wave velocity (PWV), and an increase in pulse pressure (PP) beyond the sixth decade. However, the trajectories of PWV and PP diverge with advancing age. There is an increased prevalence of salt-sensitive hypertension with advancing age that is, in part, mediated by marinobufagenin, an endogenous sodium pump ligand.
摘要
随着年龄增长会出现显著的血流动力学变化，导致高血压的流行日益加剧。中心动脉特性的改变在这些血流动力学变化中起主要作用。这些改变的特征是主动脉扩张性最初下降、舒张压升高，随后脉搏波速度（PWV）急剧增加，以及在60岁以后脉压（PP）增加。然而，PWV和PP的轨迹会随着年龄的增长而出现分歧。随着年龄的增长，盐敏感性高血压的患病率增加，部分原因是由内源性钠泵配体海蟾蜍精介导的。
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