帕金森病患者接受和未接受深部脑刺激的神经病理学比较。

Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation.

作者信息

Pal Gian D, Ouyang Bichun, Serrano Geidy, Shill Holly A, Goetz Christopher, Stebbins Glenn, Metman Leo Verhagen, Driver-Dunckley Erika, Mehta Shyamal H, Caviness John N, Sabbagh Marwan N, Adler Charles H, Beach Thomas G

机构信息

Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.

Banner Sun Health Research Institute, Sun City, Arizona, USA.

出版信息

Mov Disord. 2017 Feb;32(2):274-277. doi: 10.1002/mds.26882. Epub 2016 Dec 2.

DOI:10.1002/mds.26882

PMID:27911008

Abstract

BACKGROUND

The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions.

METHODS

PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score.

RESULTS

DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found.

CONCLUSIONS

STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons. © 2016 International Parkinson and Movement Disorder Society.

摘要