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[2009 - 2010年新疆偏远农村地区血脂异常的流行病学特征]

[Epidemiological characteristics of dyslipidemia in remote rural areas of Xinjiang, 2009-2010].

作者信息

Wang Y L, Yan Y Z, He J, Ma J L, Zhang M, Zhang J Y, Liu J M, Li S G, Niu Q, Rui D S, Ma R L, Guo H, Ding Y S, Guo S X

机构信息

Department of Public Health, School of Medicine, Shihezi University; Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi 832000, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Nov 6;50(11):996-1000. doi: 10.3760/cma.j.issn.0253-9624.2016.11.014.

Abstract

This study aimed to estimate the prevalence of dyslipidemia, hypertriglyceridemia, hypercholesterolemia, high blood low density lipoprotein cholesterol (LDL-C), and low blood high density lipoprotein cholesterol (HDL-C) in remote rural areas of Xinjiang and analyze these indicators' epidemiological characteristics. A survey of 13 000 individuals (aged ≥18 years) was conducted using a four-stage cluster random sampling method in Jiashi, Xinyuan, Aheqi, and Shawan Counties, Xinjiang, in 2009-2010. After nonpermanent residents were excluded, 12 154 individuals were included in this study. Questionnaire and physical examinations were conducted, including collection of fasting blood to detect TG, TC, LDL-C, and HDL-C. The results were calculated after complex weighting and compared according to the prevalence of different gender and age groups. The overall levels of TG, TC, LDL-C, and HDL-C were 1.34±1.09, 4.45±1.16, 2.36±0.86, and 1.37±0.58 mmol/L, respectively. After complex weighting, the overall prevalence of dyslipidemia was 35.4%; that among men (42.9%) was greater than that among women (29.5%; χ=234.19, 0.001), and the prevalence was 35.9%, 34.5%, and 35.1% (χ=1.52, 0.467) in participants aged 18-44, 45-59, and ≥60 years, respectively. The overall prevalence of hypertriglyceridemia was 11.4%; that among men (13.5%) was greater than that among women (9.8%; χ= 40.72, 0.001), and the prevalence was 9.6%, 13.0%, and 13.2% (χ=38.71, 0.001) in participants aged 18-44, 45-59, and ≥60 years, respectively. The prevalence of hypercholesterolemia was 5.7%; that among men(5.0%) was greater than that among women (6.2%; χ=6.95, 0.008), and the prevalence was 3.5%, 7.4%, and 8.4% (χ=105.24, 0.001) in participants aged 18-4, 45-59, and ≥60 years, respectively. The prevalence of high blood LDL-C was 2.8%, and there was no significant difference between men (3.0%) and women (2.4%; χ=1.43, 0.231); the prevalence was 3.5%, 7.4%, and 8.4% (χ=42.81, 0.001) in participants aged 18-44, 45-59, and ≥60 years, respectively. The prevalence of low blood HDL-C was 24.0%; that among men (31.6%) was greater than that among women (18.0%; χ=304.02, 0.001), and the prevalence was 27.8%, 20.6% and 19.5% (χ=96.61, 0.001) in participants aged 18-44, 45-59, and ≥ 60 years, respectively. Low blood HDL-C was the main type of dyslipidemia among the population in remote rural areas of Xinjiang. The prevalence of dyslipidemia among men was greater than that among women, and there was a trend of younger men than women showing dyslipidemia.

摘要

本研究旨在评估新疆偏远农村地区血脂异常、高甘油三酯血症、高胆固醇血症、高血低密度脂蛋白胆固醇(LDL-C)和低血高密度脂蛋白胆固醇(HDL-C)的患病率,并分析这些指标的流行病学特征。2009年至2010年,采用四阶段整群随机抽样方法,对新疆伽师、新源、阿合奇和沙湾县的13000名(年龄≥18岁)个体进行了调查。排除非常住人口后,本研究纳入了12154名个体。进行了问卷调查和体格检查,包括采集空腹血以检测甘油三酯(TG)、总胆固醇(TC)、LDL-C和HDL-C。结果经过复杂加权计算,并根据不同性别和年龄组的患病率进行比较。TG、TC、LDL-C和HDL-C的总体水平分别为1.34±1.09、4.45±1.16、2.36±0.86和1.37±0.58 mmol/L。经过复杂加权后,血脂异常的总体患病率为35.4%;男性患病率(42.9%)高于女性(29.5%;χ²=234.19,P<0.001),18-44岁、45-59岁和≥60岁参与者的患病率分别为35.9%、34.5%和35.1%(χ²=1.52,P=0.467)。高甘油三酯血症的总体患病率为11.4%;男性患病率(13.5%)高于女性(9.8%;χ²=40.72,P<0.001),18-44岁、45-59岁和≥60岁参与者的患病率分别为9.6%、13.0%和13.2%(χ²=38.71,P<0.001)。高胆固醇血症的患病率为5.7%;男性患病率(5.0%)低于女性(6.2%;χ²=6.95,P=0.008),18-44岁、45-59岁和≥60岁参与者的患病率分别为3.5%、7.4%和8.4%(χ²=105.24,P<0.001)。高血LDL-C的患病率为2.8%,男性(3.0%)和女性(2.4%)之间无显著差异(χ²=1.43, P=0.231);18-44岁、45-59岁和≥60岁参与者的患病率分别为3.5%、7.4%和8.4%(χ²=42.81,P<0.001)。低血HDL-C的患病率为24.0%;男性患病率(31.6%)高于女性(18.0%;χ²=304.02,P<0.001),18-44岁、45-59岁和≥60岁参与者的患病率分别为27.8%、20.6%和19.5%(χ²=96.61,P<0.001)。低血HDL-C是新疆偏远农村地区人群中血脂异常的主要类型。男性血脂异常的患病率高于女性,且男性血脂异常呈现出比女性更年轻化的趋势。

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