Gas6作为肝纤维化的一种潜在非侵入性生物标志物。

Gas6 as a putative noninvasive biomarker of hepatic fibrosis.

作者信息

Bellan Mattia, Pogliani Gabriele, Marconi Cecilia, Minisini Rosalba, Franzosi Lisa, Alciato Federica, Magri Andrea, Avanzi Gian Carlo, Pirisi Mario, Sainaghi Pier Paolo

机构信息

Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.

Division of Internal Medicine, "AOU Maggiore della Carità", Corso Mazzini 18, 28100 Novara, Italy.

出版信息

Biomark Med. 2016 Dec;10(12):1241-1249. doi: 10.2217/bmm-2016-0210. Epub 2016 Dec 7.

DOI:10.2217/bmm-2016-0210

PMID:27924629

Abstract

AIM

To evaluate serum growth arrest-specific gene 6 (Gas6) concentration as a biomarker of liver fibrosis progression.

MATERIALS & METHODS: One hundred and thirteen consecutive patients affected by chronic liver disease underwent transient elastography, Gas6 measurement and, if clinically indicated, liver biopsy.

RESULTS

Gas6 concentration was directly correlated to liver stiffness (r = 0.67; p < 0.0001) and was significantly higher in patients with advanced fibrosis (Ishak 4-5; p < 0.001). A plasma concentration <30 ng/ml Gas6 ruled out fibrosis with 84% sensitivity and 56% specificity, while values >42 ng/ml identified severe fibrosis with a sensitivity of 64% and a specificity of 95%; the diagnostic accuracy was comparable to that of transient elastography.

CONCLUSION

Gas6 is a novel biomarker of liver fibrosis, with a potential clinical and pathophysiological relevance.

摘要

目的

评估血清生长停滞特异性基因6（Gas6）浓度作为肝纤维化进展生物标志物的价值。

材料与方法

113例连续性慢性肝病患者接受了瞬时弹性成像、Gas6检测，如有临床指征则进行肝活检。

结果

Gas6浓度与肝脏硬度直接相关（r = 0.67；p < 0.0001），在晚期纤维化患者（Ishak 4 - 5级）中显著升高（p < 0.001）。血浆Gas6浓度<30 ng/ml时排除纤维化的敏感性为84%，特异性为56%；而浓度>42 ng/ml时识别严重纤维化的敏感性为64%，特异性为95%；诊断准确性与瞬时弹性成像相当。