轴突微小RNA：轴突发育过程中的定位、功能及调控机制
Axonal microRNAs: localization, function and regulatory mechanism during axon development.
作者信息
Wang Bin, Bao Lan
机构信息
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
出版信息
J Mol Cell Biol. 2017 Apr 1;9(2):82-90. doi: 10.1093/jmcb/mjw050.
Subcellular localization and translation of messenger RNAs are essential for the regulation of neuronal development and synaptic function. As post-transcriptional regulators, microRNAs (miRNAs) have been emerging as central players in the development and maturation of the nervous system. Recent discoveries reveal the critical functions of miRNAs in the axon of neurons via multiple pathways of molecular regulation. Here, we introduce methods for isolating axonal miRNAs and review recent findings on the localization and function as well as regulatory mechanism of axonal miRNAs during axon development.
信使核糖核酸的亚细胞定位和翻译对于神经元发育和突触功能的调节至关重要。作为转录后调节因子，微小核糖核酸（miRNA）已成为神经系统发育和成熟过程中的核心参与者。最近的发现揭示了miRNA通过多种分子调节途径在神经元轴突中的关键功能。在这里，我们介绍了分离轴突miRNA的方法，并综述了轴突miRNA在轴突发育过程中的定位、功能以及调节机制的最新研究成果。
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