Zhao Yanhua, Huang Lili, Xu Huan, Wu Guangxi, Zhu Mengyi, Tian Jie, Wang Hao, Wang Xiangrui, Yu Weifeng, Yang Liqun, Su Diansan
Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Mediators Inflamm. 2016;2016:3271579. doi: 10.1155/2016/3271579. Epub 2016 Nov 13.
Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1 and IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.
术后认知功能障碍（POCD）会增加手术后的发病率和死亡率。但其潜在机制尚不清楚。虽然年龄现在被认为是POCD的首要风险因素，但针对成年人术后认知功能的研究结果一直存在争议，而且关于非常年轻的成年人个体的数据也很缺乏。本研究调查了2个月大的小鼠在麻醉和手术后海马体中的空间参考记忆、白细胞介素-1（IL-1）、白细胞介素-6（IL-6）以及小胶质细胞激活的变化。我们发现，术后6小时海马体中的IL-1和IL-6增加。术后6至24小时海马体中的小胶质细胞被深度激活。然而，在这些小鼠中未发现明显的行为变化。这些结果表明，尽管麻醉和手术导致了神经炎症，但后者不足以损害年轻成年小鼠的空间参考记忆。
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