肾交感神经去神经支配治疗心房颤动作用的实验证据
Experimental Evidence Of The Role Of Renal Sympathetic Denervation For Treating Atrial Fibrillation.
作者信息
Linz Dominik, Ukena Christian, Wolf Milan, Linz Benedikt, Mahfoud Felix, Böhm Michael
机构信息
Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes.
出版信息
J Atr Fibrillation. 2014 Oct 31;7(3):1128. doi: 10.4022/jafib.1128. eCollection 2014 Oct-Nov.
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. In addition to mechanisms such as atrial stretch and atrial remodeling, also the activity of the autonomic nervous system has been suggested to contribute to the progression from paroxysmal to persistent AF. Catheter-based renal denervation (RDN) was introduced as a minimally invasive approach to reduce renal and whole body sympathetic activation which may result in atrial antiarrhythmic effects under some pathophysiological conditions. This review focuses on the potential effects of RDN on different arrhythmogenic mechanisms in the atrium and discusses potential anti-remodeling effects in hypertension, heart failure, and sleep apnea.
心房颤动（AF）是最常见的持续性心律失常，与显著的发病率和死亡率相关。除了心房牵张和心房重构等机制外，自主神经系统的活动也被认为有助于阵发性房颤向持续性房颤的进展。基于导管的肾去神经支配（RDN）作为一种微创方法被引入，以减少肾脏和全身交感神经激活，在某些病理生理条件下这可能导致心房抗心律失常作用。本综述重点关注RDN对心房不同致心律失常机制的潜在影响，并讨论其在高血压、心力衰竭和睡眠呼吸暂停中的潜在抗重构作用。
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