自噬依赖性危险信号传导及对低免疫原性肿瘤的适应性免疫
Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors.
作者信息
Kroemer Guido, Galluzzi Lorenzo
机构信息
Equipe 11 Labellisée par la Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
INSERM, U1138, Paris, France.
出版信息
Oncotarget. 2017 Jan 24;8(4):5686-5691. doi: 10.18632/oncotarget.13892.
Abstract
Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.
摘要
近期数据表明，在黑色素瘤和乳腺癌的小鼠模型中，自噬并不影响免疫细胞对肿瘤的自发浸润以及治疗引发的浸润。这些发现在缺乏具有治疗相关性的抗癌免疫反应的情况下获得，表明某些肿瘤内在的低免疫原性无法通过增加危险信号来弥补。
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