在疫苗接种覆盖率高的地区，13价肺炎球菌疫苗未涵盖的血清型作为急性中耳炎伴自发性鼓膜穿孔病因的研究
Serotypes not Included in 13-Valent Pneumococcal Vaccine as Causes of Acute Otitis Media with Spontaneous Tympanic Membrane Perforation in a Geographic Area with High Vaccination Coverage.
作者信息
Marchisio Paola, Esposito Susanna, Picca Marina, Baggi Elena, Terranova Leonardo, Orenti Annalisa, Biganzoli Elia, Principi Nicola
机构信息
From the *Department of Pathophysiology and Transplantation, Pediatric Highly Intensive Care Unit, Università degli Studi di Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; †Primary Care Pediatrician, Milan, Italy; and ‡Department of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics "G.A. Maccacaro," Università degli Studi di Milan, Milan, Italy.
出版信息
Pediatr Infect Dis J. 2017 May;36(5):521-523. doi: 10.1097/INF.0000000000001485.
In 177 children living in an area with high 13-valent pneumococcal conjugate vaccine 13 coverage, who had acute otitis media complicated with spontaneous tympanic membrane perforation, Streptococcus pneumoniae was identified in the middle ear fluid of 48 (27.1%) subjects, with 37 (77.1%) cases caused by nonpneumococcal conjugate vaccine 13 serotypes.
在居住于13价肺炎球菌结合疫苗13覆盖率高的地区的177名儿童中，他们患有急性中耳炎并伴有自发性鼓膜穿孔，在48名（27.1%）受试者的中耳液中鉴定出肺炎链球菌，其中37例（77.1%）由非13价肺炎球菌结合疫苗血清型引起。
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