Departments of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Am J Hematol. 2017 Mar;92(3):292-296. doi: 10.1002/ajh.24626. Epub 2017 Feb 3.
The category of acute erythroid leukemia was significantly revised in the recently published 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms. In the previous 2008 WHO classification, acute erythroid leukemia was categorized into two subtypes: erythroleukemia and pure erythroid leukemia (PEL), whereas in the 2016 WHO update, erythroleukemia was merged into myelodysplastic syndrome, and PEL becomes the only type of acute erythroid leukemia. PEL is a rare and aggressive form of acute leukemia whose biology remains poorly characterized. In this review, we discuss the clinicopathologic features, diagnosis, putative pathogenesis, and molecular biology of PEL, with an overview of novel concepts and future directions in this area.
急性红细胞白血病的分类在最近发布的 2016 年版世界卫生组织（WHO）髓系肿瘤分类中得到了显著修订。在之前的 2008 年 WHO 分类中，急性红细胞白血病分为两个亚型：红白血病和纯红细胞白血病（PEL），而在 2016 年 WHO 更新版中，红白血病被归入骨髓增生异常综合征，PEL 成为急性红细胞白血病的唯一类型。PEL 是一种罕见且侵袭性的急性白血病，其生物学特性仍知之甚少。在这篇综述中，我们讨论了 PEL 的临床病理特征、诊断、可能的发病机制和分子生物学，并概述了该领域的新概念和未来方向。
