微小 RNA 在肾上腺肿瘤病理生理学中的作用。
The role of microRNAs in the pathophysiology of adrenal tumors.
机构信息
Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, University of Sydney, Australia.
Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, University of Sydney, Australia; University of Sydney Endocrine Surgery Unit, Royal North Shore Hospital, Sydney, St Leonards, Sydney, NSW, Australia.
出版信息
Mol Cell Endocrinol. 2017 Nov 15;456:36-43. doi: 10.1016/j.mce.2016.12.011. Epub 2016 Dec 20.
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression in a sequence-specific manner. Due to its association with an assortment of diseases, miRNAs have been extensively studied in the last decade. In this review, the current understanding of the role of miRNAs in the pathophysiology of adrenal tumors is discussed. The recent contributions of high-throughput miRNA profiling studies have identified miRNAs that have functional and molecular roles in adrenal tumorigenesis. With respect to the biological heterogeneity of adrenal tumors and the limitations of the current treatments, an improved understanding of miRNAs may hold potential diagnostic and therapeutic value to facilitate better clinical management.
微小 RNA（miRNAs）是一类小的非编码 RNA，以序列特异性的方式调节基因表达。由于其与多种疾病相关，miRNAs 在过去十年中得到了广泛的研究。在这篇综述中，讨论了目前对 miRNAs 在肾上腺肿瘤病理生理学中的作用的理解。高通量 miRNA 分析研究的最新贡献确定了在肾上腺肿瘤发生中具有功能和分子作用的 miRNAs。鉴于肾上腺肿瘤的生物学异质性和当前治疗方法的局限性，对 miRNAs 的深入了解可能具有潜在的诊断和治疗价值，有助于更好地进行临床管理。
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